Crohn's Disease Symptoms

  • Symptoms

    An individual's symptoms depend on where in the digestive tract the disease is flaring, and how severe it is Table 01.

    Most people have involvement of the ileum, the lower part of the small intestine, causing abdominal pain and diarrhea. Abdominal pain is common after eating, especially in the lower right area.

    Diarrhea is often present, and tends to be urgent if the rectum is involved. Observable blood in the stool may occur intermittently, and can be serious and persistent enough to lead to anemia. Some people also experience low-grade fever, nausea, and vomiting. If the anus is involved, fissures or cracks may be evident, and fistulas and abscesses may form.

    Some people also have inflammation in places other than their intestines, and may develop skin or mouth lesions, pains in the joints, and eye irritation.

    With severe disease, weight loss and extreme fatigue due to nutrient and blood loss may develop, and may require hospitalization to stabilize the individual. High fever, vomiting, severe pain, and weakness can indicate an emergency, and may require immediate evaluation of an infection or an intestinal blockage or perforation.

    In children, delayed development and poor growth may be evident before any other symptoms are apparent.

    Table 1.  Symptoms of Crohn's Disease

    Common but periodic symptoms
    Cramping pain
    Diarrhea, possibly with visible blood
    Fever
    Nausea
    Weight loss
    Fatigue
    Severe symptoms
    Sores and bleeding around anus
    Sores and bleeding in mouth
    Skin lesions
    Joint pains
    Itchy or irritated eyes
    Children weight loss or slowing of growth rate
    Symptoms requiring immediate medical evaluation
    Fever
    Severe pain
    Vomiting
    Weakness
  • Risk Factors

    Crohn's disease usually starts in childhood or early adulthood. It tends to run in families and has a high incidence in Jews. Most cases of Crohn's disease start before age 30, and a second smaller peak of incidence occurs when people are in their fifties and sixties. About 20% of people diagnosed have a relative who also has inflammatory bowel disease, most often a brother or sister.

    Jewish people of European descent have a fourfold higher incidence than the general population.

    Smoking is associated with an increased risk, especially of disease recurrence following surgery.

Recommended Reading

Meet the Pharmacists

I'm Kristen Dore, PharmD. Welcome to PDR Health!

Check out my latest blog post on heartburn medication

Crohn's Disease Related Drugs

Crohn's Disease Related Conditions