Brand name:

Sinequan

Generic name: Doxepin hydrochloride

Why is Sinequan prescribed?

Sinequan is used in the treatment of depression and anxiety. It helps relieve tension, improve sleep, elevate mood, increase energy, and generally ease the feelings of fear, guilt, apprehension, and worry most people experience. It is effective in treating people whose depression and/or anxiety is psychological, associated with alcoholism, or a result of another disease (cancer, for example) or psychotic depressive disorders (severe mental illness). It is in the family of drugs called tricyclic antidepressants.

Most important fact about Sinequan

Serious, sometimes fatal, reactions have occurred when Sinequan is used in combination with drugs known as MAO inhibitors, including the antidepressants phenelzine andtranylcypromine. Any drug of this type should be discontinued at least 2 weeks prior to starting treatment with Sinequan, and you should be carefully monitored by your doctor.

If you are taking any prescription or nonprescription drugs, consult your doctor before taking Sinequan.

How should you take Sinequan?

Take this medication exactly as prescribed. It may take several weeks for you to feel better.

• If you miss a dose...
  If you are taking several doses a day, take the missed dose as soon as you remember, then take any remaining doses for that day at evenly spaced intervals. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Never take 2 doses at the same time.

If you are taking a single dose at bedtime and do not remember until the next morning, skip the dose. Do not take a double dose to make up for a missed one.

• Storage instructions...
  Store at room temperature.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Sinequan.

• Side effects may include:
  Blurred vision, constipation, dizziness, drowsiness, dry mouth, itchy or scaly skin (pruritus), light sensitivity, low blood pressure, nausea, rapid or irregular heartbeat, rash, trouble urinating, water retention

Why should Sinequan not be prescribed?

If you are sensitive to or have ever had an allergic reaction to Sinequan or similar antidepressants, you should not take this medication. Make sure that your doctor is aware of any drug reactions that you have experienced.

Unless you are directed to do so by your doctor, do not take this medication if you have the eye condition known as glaucoma or difficulty urinating.

Special warnings about Sinequan

In clinical studies, antidepressants increased the risk of suicidal thinking and behavior in children and adolescents with depression and other psychiatric disorders. Anyone considering the use of Sinequan or any other antidepressant in a child or adolescent must balance this risk with the clinical need. Sinequan is not approved for treating anyone less than 12 years old.

Additionally, the progression of major depression is associated with a worsening of symptoms and/or the emergence of suicidal thinking or behavior in both adults and children, whether or not they are taking antidepressants. Individuals being treated with Sinequan and their caregivers should watch for any change in symptoms or any new symptoms that appear suddenly—especially agitation, anxiety, hostility, panic, restlessness, extreme hyperactivity, and suicidal thinking or behavior—and report them to the doctor immediately. Be especially observant at the beginning of treatment or whenever there is a change in dose.

Sinequan may cause you to become drowsy or less alert; driving or operating dangerous machinery or participating in any hazardous activity that requires full mental alertness is not recommended.

Notify your doctor or dentist that you are taking Sinequan if you have a medical emergency, and before you have surgery or dental treatment.

Possible food and drug interactions when taking Sinequan

Alcohol increases the danger in a Sinequan overdose. Do not drink alcohol while taking this medication.

Never combine Sinequan with drugs known as MAO inhibitors. Medications in this category include the antidepressants phenelzine and tranylcypromine.

If you are switching from fluoxetine, wait at least 5 weeks after your last dose of fluoxetine before starting Sinequan.

If Sinequan is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Sinequan with the following: