Abraxane

Generic Name: Paclitaxel Protein-bound Particles

  • What is Abraxane?

    Abraxane is a medicine used to treat advanced breast cancer after failure of combination therapy for disease that has spread or relapsed within 6 months of therapy. Abraxane is administered intravenously (through a vein in your arm).

  • What is the most important information I should know about Abraxane?

    Abraxane can cause a decrease in neutrophil counts in your blood (a type of blood cell that fights infections). This may increase your risk of developing an infection. Abraxane can also cause low platelet counts (type of blood cells that form clots to help stop bleeding) or low red blood cell counts. Your doctor will monitor your blood cell counts before you start Abraxane and regularly during your treatment.

    Abraxane can cause peripheral neuropathy, which is a nerve disorder. Tell your doctor immediately if you experience numbness or tingling of your hands or feet, pain, or unusual weakness of your legs or arms.

    If you have liver impairment, exposure and toxicity of Abraxane can increase. Your doctor will also monitor your liver function while you are receiving this medication. Tell your doctor if you have severe liver problems.

    Abraxane contains albumin (human), which can increase your risk of getting a certain viral infection. Tell your doctor if you develop a fever or other symptoms of an infection.

    Abraxane can cause harm to your unborn baby if you receive it during pregnancy. If you are a man, do not plan to father a child while you are receiving Abraxane. Tell your doctor immediately if you are pregnant or plan to become pregnant.

    Tell your doctor if you experience persistent symptoms of vomiting, diarrhea, dehydration, cough or breathing difficulties, or signs of an allergic reaction after Abraxane administration.

  • Who should not take Abraxane?

    Your doctor will not administer Abraxane if you are allergic to it or any of its ingredients, or if you have a low neutrophil count.

  • What should I tell my doctor before I take the first dose of Abraxane?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Abraxane. Also, talk to your doctor about your complete medical history, especially if you have liver or kidney problems, are a man planning to father a child, or are pregnant, plan to become pregnant, or are breastfeeding.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: Your doctor will prescribe the appropriate dose for you based on your weight.

    If you have severe liver impairment or experience severely low neutrophil counts or severe peripheral neuropathy, your doctor will adjust the dose appropriately.

  • How should I take Abraxane?

    Your doctor will administer Abraxane intravenously through a needle placed in a vein. It takes about 30 minutes to give you the full dose of Abraxane. Your doctor will tell you how often you should receive Abraxane.

  • What should I avoid while taking Abraxane?

    Do not miss your scheduled appointment to receive Abraxane.

  • What are possible food and drug interactions associated with Abraxane?

    If Abraxane is used with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to tell your doctor if you are taking any of the following prior to treatment with Abraxane: carbamazepine, cimetidine, erythromycin, fluoxetine, gemfibrozil, HIV infection (AIDS) medications (such as efavirenz, indinavir, nelfinavir, nevirapine, ritonavir, or saquinavir), ketoconazole, phenytoin, or rifampicin.

  • What are the possible side effects of Abraxane?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: abnormal heartbeat, changes in your liver function tests, decreased blood cell counts, diarrhea, fever, hair loss, infections, joint or muscle pain, nausea, numbness or tingling in your hands or feet, shortness of breath, tiredness, weakness

  • Can I receive Abraxane if I am pregnant or breastfeeding?

    Abraxane can cause harm to your unborn baby if you receive it during pregnancy. The effects of Abraxane during breastfeeding are unknown. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of Abraxane?

    Contact your doctor if you miss your scheduled appointment to receive Abraxane.

  • How should I store Abraxane?

    Your doctor will store this medication for you.