Generic Name: Zafirlukast

  • What is Accolate?

    Accolate is used for the long-term treatment of asthma in adults and children 5 years and older.
  • What is the most important information I should know about Accolate?

    Accolate will not stop an asthma attack once it starts. You will still need to use an airway-opening medication when an attack occurs. Also, this drug may cause liver problems (see "What are the possible side effects of this medication?" for symptoms).
  • Who should not take Accolate?

    Do not begin treatment with Accolate if you are allergic to any of its ingredients.
  • What should I tell my doctor before I take the first dose of Accolate?

    Tell your doctor about all prescription, over-the-counter, and herbal medication you are taking before beginning treatment with Accolate. Also talk to your doctor about your complete medical history, especially if you have liver problems or you are pregnant or breastfeeding.
  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults and children 12 years and older: The recommended dose is 20 milligrams (mg) twice daily.

    Children 5-11 years: The recommended dose is 10 mg twice daily.

  • How should I take Accolate?

    A full stomach can reduce Accolate's effectiveness. You should take it at least 1 hour before or 2 hours after a meal.
  • What should I avoid while taking Accolate?

    While taking Accolate, avoid stopping—or even cutting down on—any other asthma medication you are using unless your doctor recommends it. Accolate is not an airway-opening medication. You will still need an inhaler to stop an attack.
  • What are possible food and drug interactions associated with Accolate?

    If Accolate is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Accolate with aspirin, astemizole, blood-thinning drugs, carbamazepine, cyclosporine, erythromycin, heart and blood pressure medications, phenytoin, terfenadine, theophylline, and tolbutamide.
  • What are the possible side effects of Accolate?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: accidental injury, back pain, bone/joint pain, diarrhea, dizziness, fever, headache, infection, muscle pain, nausea, upset stomach, vomiting

    Cases of life-threatening liver failure have been reported in people taking Accolate. Contact your doctor immediately if you develop signs of a liver problem, including flu-like symptoms, jaundice (yellowing of the skin and eyes), itching, loss of appetite, nausea, sleepiness, or stomach pain.

  • Can I receive Accolate if I am pregnant or breastfeeding?

    The effects of Accolate during pregnancy and breastfeeding are unknown. Talk with your doctor before taking this drug if you are pregnant, plan to become pregnant, or are breastfeeding.
  • What should I do if I miss a dose of Accolate?

    Take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Do not take 2 doses at once.
  • How should I store Accolate?

    Store at room temperature, in a dark place.