Accupril
Generic Name: Quinapril
What is Accupril?
Accupril, a medication known as an angiotensin-converting enzyme (ACE) inhibitor, is used to treat high blood pressure. It can be taken alone or in combination with a thiazide diuretic such as hydrochlorothiazide. Accupril is also used in combination with other drugs to treat congestive heart failure.What is the most important information I should know about Accupril?
When used in the second and third trimesters of pregnancy, Accupril may cause severe harm or death to your unborn baby. Accupril should be discontinued as soon as possible if you become pregnant.A rare but serious side effect known as angioedema (swelling of the face, extremities, eyes, lips, tongue; difficulty in swallowing or breathing) may occur. If such signs or symptoms occur, stop taking Accupril and immediately seek medical attention.
Accupril may cause yellowing of the skin or eyes, which may be a sign of liver dysfunction. Notify your doctor immediately if this happens.
Lightheadedness may occur, especially during the first few days of therapy, and should be reported to your doctor. If you faint, do not take Accupril until you consult with your doctor. Inadequate fluid intake or excessive sweating, diarrhea, or vomiting can lead to a fall in blood pressure and result in lightheadedness and fainting.
Prior to any surgery and/or anesthesia, inform your doctor that you are taking Accupril.
Promptly report any signs of infection, such as a sore throat or fever. Accupril may lower your white blood cells which fight infections.
Who should not take Accupril?
Do not begin treatment with Accupril if you are allergic to any of its ingredients, or if you have had reactions, such as angioedema, to another ACE inhibitor.What should I tell my doctor before I take the first dose of Accupril?
Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Accupril. Also, talk to your doctor about your complete medical history, especially if you have kidney problems, systemic lupus erythematosus or scleroderma (diseases that affect the immune system); or are undergoing surgery while being treated with this drug.What is the usual dosage?
The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.High Blood Pressure
Adults: The usual starting dose is 10-20 milligrams (mg) once daily if not taking Accupril with diuretics. The dose will be adjusted according to blood pressure response at intervals of at least 2 weeks. Afterwards, the dose may range from 20-80 mg daily. If used with a diuretic, an initial Accupril dose of 5 mg should be used and then increased to reach the optimal response. Elderly patients are recommended to start with an initial dose of 10 mg once daily.
Your doctor will prescribe the appropriate dosage for you if you have kidney problems.
Heart Failure
Adults: The usual starting dose is 5 mg twice daily. The dose should be increased at weekly intervals until an effective dose is reached. Afterwards, the dose may range from 20-40 mg given daily in 2 equally divided doses.
Your doctor will prescribe the appropriate dosage for you if you have kidney problems.
How should I take Accupril?
Accupril should be taken exactly as directed.What should I avoid while taking Accupril?
Avoid inadequate fluid intake, excessive sweating, and potassium supplements or salt substitutes containing potassium.What are possible food and drug interactions associated with Accupril?
If Accupril is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Accupril with diuretics (for example, furosemide, hydrochlorothiazide, spironolactone), injectable gold (sodium aurothiomalate), lithium, magnesium, potassium supplements, salt substitutes containing potassium, and tetracycline.What are the possible side effects of Accupril?
Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.Side effects may include: headache, dizziness, fatigue, coughing, nausea, vomiting, stomach pain
Can I receive Accupril if I am pregnant or breastfeeding?
Do not take Accupril during the second and third trimesters, as it may cause severe harm or death to your unborn baby. Accupril is found in breast milk, so caution should be exercised when administering Accupril to nursing women. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.What should I do if I miss a dose of Accupril?
If you miss a dose of Accupril, take the missed dose as soon as you remember it. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.How should I store Accupril?
Store at room temperature, and protect from light.
I'm Beth Isaac, PharmD. Welcome to PDR Health!
