Generic Name: Spironolactone

  • What is Aldactazide?

    Aldactazide is used to treat high blood pressure and other conditions that require the elimination of excess fluid from the body. These conditions include congestive heart failure, cirrhosis of the liver, and kidney disease. Aldactazide combines two diuretic "water pill" drugs that help your body produce and eliminate urine, control high blood pressure, and minimize the loss of potassium. It can be used in pregnancy to eliminate excess fluid under certain circumstances.

  • What is the most important information I should know about Aldactazide?

    If you have high blood pressure, you must take Aldactazide regularly for it to be effective. Since blood pressure declines gradually, it may be several weeks before you get the full benefit of Aldactazide; you must continue taking it even if you are feeling well. Aldactazide does not cure high blood pressure; it keeps it under control.

    The hydrochlorothiazide component of Aldactazide has been known to trigger gout and allergic reactions. It can also raise your blood sugar levels.

    Breast enlargement may develop and therapy should stop before your doctor tests for parathyroid function. Aldactazide may increase cholesterol and triglyceride levels.

    Aldactazide should be only used as prescribed to treat approved conditions.

  • Who should not take Aldactazide?

    Do not take Aldactazide if you are allergic to any of its ingredients. Also, do not take this drug if you have kidney disease or liver failure, are unable to urinate, or have high potassium levels.

  • What should I tell my doctor before I take the first dose of Aldactazide?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Aldactazide. Also, talk to your doctor about your complete medical history, especially if you have kidney or liver problems, are unable to urinate, are allergic to thiazides or sulfonamides, or have lupus erythematosus (a disease that causes skin eruptions). Your doctor should know if you are going to have surgery while on Aldactazide.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.


    Adults: For water retention due to congestive heart failure, cirrhosis of the liver, or kidney disease, the usual dosage is 100 milligrams (mg) each of spironolactone and hydrochlorothiazide daily, taken as a single dose or in divided doses. The dosage may range from 25-200 mg of each ingredient daily, depending on individual needs.

    High Blood Pressure

    Adults: The usual dose is 50-100 mg each of spironolactone and hydrochlorothiazide daily, in a single dose or divided into smaller doses.

  • How should I take Aldactazide?

    Take this medication each day as prescribed by your doctor.

  • What should I avoid while taking Aldactazide?

    Avoid potassium supplements and foods containing high levels of potassium, including salt substitutes.

    Avoid drinking alcohol.

    Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

  • What are possible food and drug interactions associated with Aldactazide?

    If Aldactazide is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Aldactazide with the following: ACE inhibitors (such as captopril, enalapril, fosinopril, lisinopril), alcohol, barbiturates such as phenobarbital, corticosteroids, digoxin, diuretics, insulin or oral antidiabetic drugs, lithium, muscle relaxants, narcotic drugs such as those containing codeine, nonsteroidal anti-inflammatory drugs, pressor amines such as norepinephrine, and potassium supplements.

  • What are the possible side effects of Aldactazide?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: breast development in males, deepening of the voice, diarrhea, dizziness, drowsiness, excessive hairiness, fever, headache, hives, irregular menstruation, lack of coordination, loss of appetite, mental confusion, muscle spasms, nausea, postmenopausal bleeding, rash, red or purple spots on the skin, restlessness, sensitivity to light, severe allergic reaction, sexual dysfunction, sluggishness, stomach bleeding, stomach ulcers, tingling, vomiting, weakness, yellow eyes and skin

  • Can I receive Aldactazide if I am pregnant or breastfeeding?

    The effects of Aldactazide during pregnancy and breastfeeding are unknown. Talk with your doctor before taking this drug if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of Aldactazide?

    If you miss a dose of Aldactazide, take the missed dose as soon as you remember it. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once. If you are unsure, ask your doctor or pharmacist for advice.

  • How should I store Aldactazide?

    Store at room temperature. Protect from light.

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