Generic Name: Spironolactone

  • What is Aldactone?

    Aldactone is a diuretic medication used to control high blood pressure. It is also used to treat hyperaldosteronism (an increase in a hormone called aldosterone which can cause an increase in blood pressure), other conditions that require the elimination of excess fluid from the body (such as congestive or severe heart failure, and kidney disease), and to treat or prevent low potassium levels in the blood.

  • What is the most important information I should know about Aldactone?

    Aldactone only controls high blood pressure; it does not cure it. You must take Aldactone regularly for it to be effective.

    If you have severe heart failure, your doctor will need to monitor your potassium levels during treatment with Aldactone.

  • Who should not take Aldactone?

    Do not take Aldactone if you are allergic to any of its ingredients, and if you have kidney disease, difficulty urinating, or high potassium levels.

  • What should I tell my doctor before I take the first dose of Aldactone?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Aldactone. Also, talk to your doctor about your complete medical history, especially if you have kidney problems, liver disease, severe heart failure, are taking potassium supplements, or if you are going to have surgery while taking Aldactone.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    High Blood Pressure

    Adults: The usual starting dose is 50-100 milligrams (mg) daily in single or divided doses. This medication may be given with another diuretic or with other blood pressure medications.

    Fluid Retention

    Adults: The usual starting dose is 100 mg daily either in single or divided doses; doses may vary between 25-200 mg daily.



    Adults: The usual dose of Aldactone is between 100-400 mg per day.

    Potassium Loss

    Adults: The usual dose is 25-100 mg per day when potassium cannot be replaced with a supplement.

    Severe Heart Failure

    Adults: The usual starting dose is 25 mg once daily, depending on your potassium levels and kidney function.

  • How should I take Aldactone?

    Take this medication each day as prescribed by your doctor.

  • What should I avoid while taking Aldactone?

    Avoid potassium supplements and foods containing high levels of potassium, including salt substitutes. Also avoid drinking alcohol.

    Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink.

  • What are possible food and drug interactions associated with Aldactone?

    If Aldactone is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Aldactone with the following: ACE inhibitors (such as captopril, enalapril, fosinopril, lisinopril), alcohol, barbiturates such as phenobarbital, corticosteroids, digoxin, foods or products with high potassium contents, indomethacin, lithium, muscle relaxants, narcotic drugs such as those containing codeine, nonsteroidal anti-inflammatory drugs, norepinephrine, other diuretics, and other high blood pressure medications.

  • What are the possible side effects of Aldactone?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: breast development in males, deepening of voice, diarrhea, drowsiness, excessive hairiness, fever, headache, hives, irregular menstruation, lack of coordination, mental confusion, postmenopausal bleeding, severe allergic reaction, sexual dysfunction, skin eruptions, sleepiness, stomach bleeding, stomach cramps, stomach inflammation, ulcers, vomiting

  • Can I receive Aldactone if I am pregnant or breastfeeding?

    The effects of Aldactone during pregnancy and breastfeeding are unknown. Talk with your doctor before taking this drug if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of Aldactone?

    Take the missed dose as soon as you remember it. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

  • How should I store Aldactone?

    Store at room temperature and protect from light.

Starting a Cholesterol Drug?

Our seven-week newsletter series, written by a pharmacist, will help you learn about your medication.
Sign Up

Meet the Pharmacists

I'm Beth Isaac, PharmD. Welcome to PDR Health!

Check out my latest post on cholesterol drugs.

Aldactone Related Drugs