Amitriptyline hydrochloride and perphenazine

Generic Name: Perphenazine

  • What is Amitriptyline hydrochloride and perphenazine?

    Amitriptyline and perphenazine is a combination antidepressant medicine used to treat anxiety, agitation, and/or depression. This medication is also used in schizophrenic patients with depressive symptoms.

  • What is the most important information I should know about Amitriptyline hydrochloride and perphenazine?

    This medication is not recommended for use in children.

    Antidepressant medicines may increase suicidal thoughts or actions in some children, teenagers, and young adults when first started. Depression and other serious mental illnesses are the most important causes of suicidal thoughts and actions. You may have a high risk of having suicidal thoughts or actions if you have, or have a family history of, bipolar illness (also called manic-depressive illness).

    Pay close attention to any changes, especially sudden changes in mood, behaviors, thoughts, or feelings. This is very important when an antidepressant medicine is first started or when the dose is changed.

    Tell your doctor immediately if you experience any new or sudden change in your mood, behavior, thoughts, or feelings. Signs to watch for include: new or worsening depression, anxiety, or irritability; agitation, restlessness, trouble sleeping; acting aggressive; panic attacks; extreme increase in activity and talking; and suicidal thinking or behavior.

    Keep all follow-up visits as scheduled, and call your doctor between visits as needed, especially if you have concerns about symptoms.

    Do not stop taking your antidepressant medications without first talking to your doctor.

  • Who should not take Amitriptyline hydrochloride and perphenazine?

    Do not take amitriptyline and perphenazine if you are allergic to them or any of their ingredients, or if you are taking antidepressant medications known as monoamine oxidase inhibitors (MAOIs). If your doctor wants to replace the MAOI with this medication, you must wait 14 days before starting the new medicine. Do not take this medication if you have a certain blood disorder known as bone marrow suppression, or if you are recovering from a heart attack.

    Do not use amitriptyline and perphenazine if you have central nervous system (CNS) depression due to other medications, for example barbiturates (such as phenobarbital), alcohol, narcotics (such as morphine), painkillers, or allergy medications.

  • What should I tell my doctor before I take the first dose of Amitriptyline hydrochloride and perphenazine?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with amitriptyline and perphenazine. Also, talk to your doctor about your complete medical history, especially if you have trouble urinating, a history of seizure disorder, heart problems, glaucoma (high pressure in the eye), or thyroid problems.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: Your doctor will prescribe the appropriate dose for you based on your condition.

    Attempts to taper (gradually reduce the dose) or discontinue the medication should be made at specific intervals, through the guidance of your doctor.

  • How should I take Amitriptyline hydrochloride and perphenazine?

    Take amitriptyline and perphenazine as prescribed by your doctor. Do not take extra doses or take more often without asking your doctor.

  • What should I avoid while taking Amitriptyline hydrochloride and perphenazine?

    Do not stop taking amitriptyline and perphenazine without first talking to your doctor.

    Do not drive, operate dangerous machinery, or participate in any hazardous activity that requires full mental alertness until you know how this medication affects you.

    Do not drink alcohol while you are taking this medication and avoid exposure to extreme heat or organic phosphate insecticides. Your doctor will discontinue this medication several days before an elective surgery.

  • What are possible food and drug interactions associated with Amitriptyline hydrochloride and perphenazine?

    If amitriptyline and perphenazine is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining amitriptyline and perphenazine with the following: allergy medications, atropine, cimetidine, CNS depressants (such as codeine, painkillers, or phenobarbital), ethchlorvynol, flecainide, fluoxetine, guanethidine, other antidepressants, paroxetine, propafenone, quinidine, or sertraline.

  • What are the possible side effects of Amitriptyline hydrochloride and perphenazine?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: drowsiness, dry mouth, high blood pressure, mental impairments

  • Can I receive Amitriptyline hydrochloride and perphenazine if I am pregnant or breastfeeding?

    The effects of amitriptyline and perphenazine during pregnancy and breastfeeding are unknown. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of Amitriptyline hydrochloride and perphenazine?

    If you miss a dose of amitriptyline and perphenazine, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

  • How should I store Amitriptyline hydrochloride and perphenazine?

    Store at room temperature and protect from light.