Amitriptyline hydrochloride and perphenazine

  • What is Amitriptyline hydrochloride and perphenazine?

    This combination drug is used to treat patients with nervousness and/or agitation and depressed mood, or patients with depression and any of the above in association with a long-term physical disease.
  • What is the most important information I should know about Amitriptyline hydrochloride and perphenazine?

    This drug is not recommended for use in children.

    Antidepressant medications may increase suicidal thoughts or actions in some children, teenagers, and young adults when first started. Depression and other serious mental illnesses are the most important causes of suicidal thoughts and actions. Some people may have a particularly high risk of having suicidal thoughts or actions. These include people who have (or have a family history of) bipolar disorder (also called manic-depressive illness) or suicidal thoughts or actions.

    Pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings. This is very important when an antidepressant medicine is first started or when the dose is changed.

    Call the doctor right away to report new or sudden changes in mood, behavior, thoughts, or feelings. Signs to watch for include new or worsening depression, new or worsening nervousness, agitation, sleeplessness, hostility, panic attacks, restlessness, extreme hyperactivity, and suicidal thinking or behavior.

    Keep all follow-up visits as scheduled, and call the doctor between visits as needed, especially if you have concerns about symptoms.

    Do not stop taking antidepressant medications without consulting with your doctor first.

  • Who should not take Amitriptyline hydrochloride and perphenazine?

    Do not take this drug if you are sensitive to or have ever had an allergic reaction to amitriptyline or phenothiazines, or if you are taking other drugs known as monoamine oxidase inhibitors (MAOIs). This medication should also be avoided if you have a certain blood disorder known as bone marrow suppression or if you are recovering from a heart attack.
  • What should I tell my doctor before I take the first dose of Amitriptyline hydrochloride and perphenazine?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with this drug. Also, talk to your doctor about your complete medical history, especially if you have had trouble urinating or if you have a history of seizure disorders, heart problems, certain conditions of the eyes, or thyroid problems.
  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: The usual recommended dose of amitriptyline/perphenazine is one tablet of 25 mg/2 mg or 25 mg/4 mg three to four times daily, or one tablet of 50 mg/4 mg twice daily.

    The total daily dose should not exceed 200 mg of amitriptyline or 16 mg of perphenazine.

  • How should I take Amitriptyline hydrochloride and perphenazine?

    Take this drug exactly as indicated by your doctor.
  • What should I avoid while taking Amitriptyline hydrochloride and perphenazine?

    You should never stop taking this medication without consulting your doctor first. Driving or operating dangerous machinery or participating in any hazardous activity that requires full mental alertness should be avoided until you know how this drug affects you. Avoid the consumption of alcohol.
  • What are possible food and drug interactions associated with Amitriptyline hydrochloride and perphenazine?

    If amitriptyline and perphenazine is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining this medication with the following: allergy medications, other antidepressants, cimetidine, ethchlorvynol, flecainide, pain medications, propafenone, and quinidine.
  • What are the possible side effects of Amitriptyline hydrochloride and perphenazine?

    Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: drowsiness, mental impairments, high blood pressure, dry mouth

  • Can I receive Amitriptyline hydrochloride and perphenazine if I am pregnant or breastfeeding?

    The effects of this drug during pregnancy or breastfeeding are unknown; therefore, its use is not recommended. Tell your doctor immediately if you are pregnant, planning to become pregnant, or are breastfeeding.
  • What should I do if I miss a dose of Amitriptyline hydrochloride and perphenazine?

    If you miss a dose of this drug, skip it. Never take an extra dose to make up for a missed dose.
  • How should I store Amitriptyline hydrochloride and perphenazine?

    Store at room temperature and protect from light.