Amoxapine

  • What is Amoxapine?

    Amoxapine is an antidepressant used for the relief of symptoms of depression in patients with neurotic or reactive depressive disorders as well as endogenous and psychotic depression. It is also used to treat depression accompanied by anxiety or agitation.
  • What is the most important information I should know about Amoxapine?

    Amoxapine, along with other antidepressants, may increase the risk of suicidal thinking and behavior in children, adolescents, and young adults. Patients, their families, and their caregivers are encouraged to be alert to the emergence of anxiety, agitation, irritability, hostility, aggressiveness, and suicidal ideation, especially early during antidepressant treatment, and when the dose is adjusted up or down.

    Amoxapine may cause drowsiness, and impair your ability to drive or operate machinery.

    Amoxapine should not be administered with a class of drugs known as monoamine oxidase inhibitors (MAOI), as this could cause severe convulsions or death. Allow a minimum of 14 days after stopping an MAOI before starting amoxapine therapy.

    You should not use amoxapine of you are recovering from a heart attack.

    Patients in whom chronic or long-term use of amoxapine is contemplated are at higher risk of developing tardive dyskinesia, a syndrome consisting of potentially irreversible, involuntary movements.

  • Who should not take Amoxapine?

    Patients currently taking MAOIs, pediatric patients, and patients with known allergies to dubenzoxazepine compounds should not take this drug.
  • What should I tell my doctor before I take the first dose of Amoxapine?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with amoxapine. Also, talk to your doctor about your complete medical history, especially if you have been diagnosed with bipolar (manic-depressive) disorder in the past. Also, tell your doctor if you are taking any other neuroleptic drugs.
  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: The usual starting dose is 50 milligrams (mg) two or three times daily. Depending upon tolerance, dosage may be increased to 100 mg two or three times daily by the end of the first week. Increases above 300 mg daily should be made only if 300 mg daily has been ineffective during a trial period of at least two weeks. When effective dosage is established, the drug may be given in a single dose at bedtime.

    Elderly patients should start with 25 mg two to three times daily and gradually increase the dose until effective dose is established.

  • How should I take Amoxapine?

    Take this medication at bedtime exactly as directed by your physician.
  • What should I avoid while taking Amoxapine?

    Avoid other antidepressants and MOAIs.

    Avoid alcohol and central nervous system depressants.

    Since this drug may cause drowsiness, avoid performing activities that require alertness until you learn how this medication affects you.

  • What are possible food and drug interactions associated with Amoxapine?

    If amoxapine is used with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining amoxapine with the following: alcohol, antidepressants, central nervous system depressants, cimetidine, flecainide, MAOIs, propafenone, and quinidine.
  • What are the possible side effects of Amoxapine?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: drowsiness, dry mouth, constipation, blurred vision, insomnia, anxiety, restlessness, headache, fatigue

  • Can I receive Amoxapine if I am pregnant or breastfeeding?

    The effects of amoxapine during pregnancy and breastfeeding are unknown. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
  • What should I do if I miss a dose of Amoxapine?

    Skip the dose and continue with your normal dosing regimen. Never double dose.
  • How should I store Amoxapine?

    Store at room temperature.