Generic Name: Cyclobenzaprine

  • What is this medication and its most common uses?

    Amrix is a medicine used along with rest and physical therapy to relieve muscle spasms associated with short-term, painful musculoskeletal conditions. Amrix is an extended release medicine (a type of capsule that releases medicine into your body throughout the day).

  • What should I know when beginning and continuing on this medication?

    How does this medication work?

    Amrix works by relaxing your muscles, thereby relieving symptoms of discomfort.

    What are the beneficial effects of this medication and when should I begin to have results?

    What: Amrix has been shown to help relieve pain due to muscle spasms, and may relieve associated symptoms, such as tenderness and limited range of movement.

    When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Amrix exactly as your healthcare provider has prescribed.

    How do I know it is working?

    You may feel a reduction in pain and muscle spasms after you start taking Amrix. This is a good indicator that the medicine is working. Your healthcare provider may ask you questions to assess how well your symptoms are controlled.

  • What are the possible side effects of this medication?

    The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

    More common side effects may include: dry mouth, dizziness, tiredness, constipation, nausea, upset stomach, drowsiness.

    Less common side effects may include:

    Serotonin syndrome (a potentially life-threatening drug reaction that causes the body to have too much serotonin, a chemical produced by the nerve cells), with symptoms such as mental status changes (such as agitation or hallucinations), an increase in your heart rate and temperature, lack of coordination, overactive reflexes, muscle rigidity, nausea, vomiting, or diarrhea.

  • Who should not take this medication?

    Do not take Amrix if you are allergic to it or any of its ingredients.

    Do not take Amrix if you are taking certain antidepressants known as monoamine oxidase inhibitors (MAOIs) (such as tranylcypromine or phenelzine) or it has been 14 days or less since you stopped taking an MAOI.

    Do not take Amrix if you have certain heart problems, such as a recent heart attack, arrhythmias (heart rhythm problems), or heart failure.

    Do not take Amrix if you have hyperthyroidism (an overactive thyroid).

  • What should I tell my healthcare provider before I take the first dose of this medication?

    Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Amrix. Also, talk to your healthcare provider about your complete medical history, especially if you have liver problems; heart problems (including a heart attack); a history of eye problems (including glaucoma [high pressure in the eye]); have trouble emptying your bladder; or if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

    Adults: The recommended dose is 15 milligrams once a day. Your healthcare provider may increase your dose as needed.

  • How should I take this medication?

    Take Amrix exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Amrix without first talking to your healthcare provider.

    Take Amrix around the same time each day.

    Take Amrix for short periods (up to two or three weeks), as prescribed by your healthcare provider.

  • What should I avoid while taking this medication?

    Do not drive, operate heavy machinery, or engage in other dangerous activities until you know how Amrix affects you.

    Do not drink alcohol while you are taking Amrix.

  • What are the possible food and drug interactions associated with this medication?

    If Amrix is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Amrix with the following: alcohol, barbiturates (such as phenobarbital), certain antidepressants (such as amitriptyline, bupropion, sertraline, or venlafaxine), guanethidine, MAOIs, medicines that may make you sleepy (such as oxycodone or alprazolam), meperidine, tramadol, or verapamil.

  • May I receive this medication if I am pregnant or breastfeeding?

    The effects of Amrix during pregnancy and breastfeeding are unknown. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of this medication?

    If you miss a dose of Amrix, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

  • How should I store this medication?

    Store at room temperature.

Meet the Pharmacists

I'm Beth Isaac, PharmD. Welcome to PDR Health!

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