Generic Name: Clomipramine

  • What is Anafranil?

    Anafranil is an antidepressant medication known as a tricyclic antidepressant (TCA). It is used to treat obsessive-compulsive disorder (OCD).

  • What is the most important information I should know about Anafranil?

    Antidepressants can increase the risk of suicidal thinking and behavior in children, adolescents, and young adults. Patients of all ages who are started on antidepressants or are taking a new dose should be watched closely for worsening condition, suicide risk, or unusual behavior. Patients and their families should contact their doctor immediately if new symptoms develop or seem to get worse. Signs to watch for include anxiety, hostility, sleeplessness, restlessness, impulsive or dangerous behavior, and thoughts about suicide or dying.

    Anafranil may increase the risk of seizures if you have had seizures in the past or if you have other conditions that may cause seizures.

    Men taking Anafranil may experience sexual problems.

  • Who should not take Anafranil?

    Do not take Anafranil if you are allergic to the medication, any of its ingredients, or other TCAs.

    Anafranil should not be taken in combination with monoamine oxidase inhibitors (MAOIs) or within 14 days before or after treatment with an MAOI. MAOIs are a class of drugs used to treat depression, mental or emotional conditions, and Parkinson's disease.

    In addition, Anafranil should not be used during the recovery period shortly after a heart attack.

  • What should I tell my doctor before I take the first dose of Anafranil?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Anafranil. Also, talk to your doctor about your complete medical history, especially if you have ever had suicidal thoughts or behaviors, seizures, heart problems, liver disease, an overactive thyroid, glaucoma (high pressure in the eye), urinary retention (inability to urinate normally), brain tumors, impaired kidney function, or a family history of bipolar disorder, depression, or suicide.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults and children 10-17 years: The recommended starting dose is 25 milligrams (mg) daily. Your doctor may adjust your dose as necessary.

  • How should I take Anafranil?

    During dose adjustments, Anafranil should be taken in divided doses with meals in order to reduce stomach upset. After the dose adjustment period, it is best taken at bedtime to minimize daytime sleepiness.

  • What should I avoid while taking Anafranil?

    Never stop taking an antidepressant without first talking to your doctor.

    Because Anafranil can cause dizziness and drowsiness, avoid activities requiring mental alertness or coordination until you know how this medicine affects you. Also, do not drink alcohol while taking Anafranil.

    Do not take MAOIs during or within 14 days before or after Anafranil therapy.

  • What are possible food and drug interactions associated with Anafranil?

    If Anafranil is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Anafranil with the following: alcohol, agents that make you sleepy or drowsy, cimetidine, clonidine, digoxin, fluoxetine, guanethidine, MAOIs, phenobarbital, phenytoin, quinidine, and warfarin.

  • What are the possible side effects of Anafranil?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: constipation, dizziness, dry mouth, fatigue, loss of appetite, nausea, nervousness, sexual problems, sleepiness, stomach upset, sweating, vision changes, weight gain

  • Can I receive Anafranil if I am pregnant or breastfeeding?

    Pregnant women should take Anafranil only if recommended by their doctor. Anafranil can pass into breast milk and is not recommended during breastfeeding. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of Anafranil?

    If you miss a dose of Anafranil, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

  • How should I store Anafranil?

    Store in a cool, dry place in a light-resistant container.