Generic Name: Clomipramine hydrochloride

  • What is Anafranil?

    Anafranil is used to treat obsessive-compulsive disorder (OCD).
  • What is the most important information I should know about Anafranil?

    Patients with major depressive disorder (MDD) may experience worsening of their depression and/or the emergence of suicidal ideation and behavior or unusual changes in behavior. Suicide is a known risk of depression and certain other psychiatric disorders.

    During studies, seizures were the most significant risk of Anafranil use.

  • Who should not take Anafranil?

    Do not use Anafranil if you have a history of hypersensitivity to this drug or other tricyclic antidepressants.

    Anafranil should not be combined with, or taken within 14 days of, a type of drug known as a monoamine oxidase inhibitor (MAOI). In addition, Anafranil should not be used during the acute recovery period after a heart attack.

  • What should I tell my doctor before I take the first dose of Anafranil?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Anafranil. Also, talk to your doctor about your complete medical history, especially if you have ever had suicidal thoughts or behaviors; seizures; an overactive thyroid; glaucoma; urinary problems; brain tumors; impaired kidney function; or a family history of bipolar disorder, depression, or suicide.
  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: Treatment should be initiated at a dosage of 25 milligrams (mg) daily and is gradually increased, as tolerated, to approximately 100 mg during the first two weeks up to a maximum of 250 mg daily.

    Children and adolescents: The starting dose is 25 mg daily and is gradually increased during the first 2two weeks, as tolerated, up to a daily maximum of 3 mg/kg or 100 mg, whichever is smaller. The daily maximum after the titration period is 200 mg.

  • How should I take Anafranil?

    During initial titration, Anafranil should be given in divided doses with meals in order to reduce stomach upset. After the titration period, it is best taken at bedtime to minimize daytime sedation.
  • What should I avoid while taking Anafranil?

    Never stop taking an antidepressant without first talking to your doctor.

    Because Anafranil can cause dizziness and drowsiness, avoid activities requiring mental alertness or coordination until you know how this drug affects you.

    Do not drink alcohol while taking this drug.

    Do not take MAOIs during or within 14 days before or after Anafranil therapy.

  • What are possible food and drug interactions associated with Anafranil?

    If Anafranil is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Anafranil with the following: central nervous system medications, cimetidine, clonidine, digoxin, fluoxetine, guanethidine, phenobarbital, phenytoin, quinidine, and warfarin.
  • What are the possible side effects of Anafranil?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: stomach upset, dry mouth, constipation, nausea, loss of appetite, dizziness, nervousness, sexual dysfunction, fatigue, sweating, vision changes

  • Can I receive Anafranil if I am pregnant or breastfeeding?

    The effects of Anafranil during pregnancy are unknown. Tell your doctor immediately if you are pregnant or plan to become pregnant. Because Anafranil can pass into breast milk, it is important to consult your doctor before breastfeeding.
  • What should I do if I miss a dose of Anafranil?

    Take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your regular schedule. Never take 2 doses at the same time.
  • How should I store Anafranil?

    Store in a cool, dry place in a light-resistant container.