Generic Name: Drospirenone

  • What is Angeliq?

    Angeliq is a medicine that contains two kinds of hormones, estrogen and progestin. Angeliq is used to reduce moderate to severe signs of menopause such as hot flashes, dryness, itching, or burning in and around the vagina.

  • What is the most important information I should know about Angeliq?

    Do not use Angeliq to prevent heart disease, heart attacks, or strokes. Using it may increase your chances of having a heart attack, stroke, breast cancer, and blood clots. Be sure to do a monthly self-exam of your breasts, and get regular mammograms.

    Angeliq may increase your risk of developing dementia if you are >65 years old. Estrogens should be used only as long as needed. You and your doctor should talk regularly about whether you still need treatment with Angeliq.

    Angeliq contains estrogen, which can cause fluid retention, changes in thyroid levels, increased triglyceride levels, high blood pressure, increased/decreased calcium levels in the blood, vision problems, increased risk of gallbladder disease, and ovarian cancer. It can also worsen conditions you may have such as asthma, diabetes, seizures, migraines, or lupus.

    Angeliq also contains drospirenone, which may cause decreased sodium levels or increased potassium levels in the blood.

    Angeliq may affect certain laboratory test results. Make sure your doctor knows you are taking Angeliq before performing blood tests.

  • Who should not take Angeliq?

    You should not take Angeliq if you have had your uterus removed, have or have had a history of estrogen-dependent cancers (eg, breast or uterine cancer), blood clots, or unusual vaginal bleeding.

    Do not take this drug if you are allergic to any of its ingredients, had a heart attack or stroke in the past year, or if you are pregnant. You should not take Angeliq if you have any condition that causes you to have high potassium levels in the blood (eg, kidney, liver, or adrenal gland problems).

  • What should I tell my doctor before I take the first dose of Angeliq?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Angeliq. Also, talk to your doctor about your complete medical history, especially if you have asthma, seizures, migraines, endometriosis, or lupus; high blood pressure; problems with your heart, liver, thyroid, or kidneys; have high calcium levels in the blood; if you are breastfeeding; or are going to have surgery or be on bed rest for a long period of time.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: Angeliq is available in a tablet containing 0.5 milligrams (mg) of drospirenone and 1 mg of estradiol. The dosage is one tablet daily.

  • How should I take Angeliq?

    Take one tablet every day. Estrogens with or without progestins should be used at the lowest effective doses and only for as long as menopausal symptoms persist. You and your healthcare provider should talk regularly (every 3-6 months) about whether or not you still require treatment.

  • What should I avoid while taking Angeliq?

    If you are already using a product containing estrogen, you should stop taking that product before starting Angeliq. Avoid increasing your risk of heart disease by lowering blood pressure and cholesterol, losing weight, and avoiding tobacco use.

  • What are possible food and drug interactions associated with Angeliq?

    If Angeliq is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Angeliq with medications that increase the potassium in your blood, including: angiotensin-converting enzyme (ACE) inhibitors, angiotensin-II receptor antagonists, nonsteroidal anti-inflammatory drugs (NSAIDs), potassium-sparing diuretics, potassium supplements, and heparin.

    Angeliq may also interact with the following drugs: carbamazepine, erythromycin, clarithromycin, itraconazole, ketoconazole, levothyroxine, phenobarbital, rifampin, ritonavir, and St. John's wort. Grapefruit juice may increase estrogen levels in the body. It may also increase the risk of side effects. Talk to your doctor before including grapefruit and grapefruit juice in your diet while taking Angeliq.

  • What are the possible side effects of Angeliq?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: breast pain, flulike symptoms, hair loss, headache, irregular vaginal bleeding or spotting, nausea/vomiting, stomach cramps/bloating, upper respiratory infection, vaginal bleeding/discharge, increased potassium or decreased sodium levels in your blood

  • Can I receive Angeliq if I am pregnant or breastfeeding?

    Angeliq should not be used if you are pregnant. The hormone in Angeliq can pass into your breast milk. Talk with your doctor before taking this drug if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of Angeliq?

    Take the missed dose as soon as you remember it. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

  • How should I store Angeliq?

    Store at room temperature.

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I'm Beth Isaac, PharmD. Welcome to PDR Health!

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