What is Antara?Antara is used in combination with diet and exercise to reduce LDL ("bad") cholesterol, total cholesterol levels, and triglycerides, and to increase HDL ("good") cholesterol.
What is the most important information I should know about Antara?Antara may increase cholesterol excretion into the bile, leading to gallstones. Regular monitoring of liver function tests is required. If gallstones are found, Antara therapy should be discontinued.
Treatment with Antara should be discontinued if an adequate response is not obtained after 2 months of therapy at the maximal daily dose.
Your doctor should regularly check cholesterol levels, triglycerides and liver function to monitor your progress to reach your target range of cholesterol levels.
Taking other cholesterol medications such as atorvastatin, fluvastatin, lovastatin, pitavastatin (Livalo), pravastatin, rosuvastatin and simvastatin should be avoided in patients taking Antara. Concurrent use of these medications may lead to a serious side effect characterized by muscle pain, tenderness, and weakness.
Who should not take Antara?Do not take Antara if you are allergic or sensitive to fenofibrate, have gallbladder disease, develop gallstones, or have liver or severe kidney disease.
What should I tell my doctor before I take the first dose of Antara?Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Antara. Also, talk to your doctor about your complete medical history, especially if you have liver disease, gallbladder disease, gallstones, or severe kidney impairment. Also, tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding.
What is the usual dosage?The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.
Adults: For the treatment of high cholesterol, the initial dose is 130 milligrams (mg) per day. For the treatment of high triglyceride levels, the initial dose is 43-130 mg per day. Based on your response, the doctor may adjust the dosage at 4- to 8-week intervals. The maximum dose is 130 mg per day.
Adults ≥65 years: The initial dose should be limited to 43 mg per day.
Adults with kidney problems: Treatment should be started at a dose of 43 mg per day, and increased only after evaluation of the effects on kidney function.
How should I take Antara?You should follow a diet and exercise plan as directed by your doctor. You may take Antara with or without food.
What should I avoid while taking Antara?Do not neglect controlling your condition with diet and exercise, as directed by your doctor. Antara is meant to be used as part of a comprehensive treatment plan for improving cholesterol and triglyceride levels.
What are possible food and drug interactions associated with Antara?If Antara is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Antara with the following: atorvastatin, blood thinners (such as coumadin and warfarin), colesevelam, colestipol, cyclosporine, dicumarol, ezetimibe, fluvastatin, lovastatin, phenindione, pitavastatin, pravastatin, or simvastatin.
What are the possible side effects of Antara?Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.
Side effects may include: abnormal liver function tests, respiratory disorders, abdominal pain, back pain, headache, weakness, flulike symptoms, diarrhea, nausea, constipation, runny nose
Antara may cause myopathy; signs of this condition include unexplained muscle pain, weakness, or tenderness. If you experience these symptoms, tell your doctor right away.
Can I receive Antara if I am pregnant or breastfeeding?The effects of Antara during pregnancy are unknown. Tell your doctor immediately if you are pregnant, or plan to become pregnant. Antara should not be used in nursing mothers, and a decision will need to be made whether to discontinue nursing or to discontinue Antara.
What should I do if I miss a dose of Antara?If you miss a dose of Antara, take the missed dose as soon as you remember it. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once. If you are unsure, ask your doctor or pharmacist for advice.
How should I store Antara?Store in a tightly sealed container in a cool, dry place, away from sunlight.
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