Generic Name: Bupropion hydrobromide

  • What is Aplenzin?

    Aplenzin is used to treat adults with major depressive disorder.
  • What is the most important information I should know about Aplenzin?

    Antidepressants can increase the risk of suicidal thinking and behavior in children and teenagers. Both adult and pediatric patients taking antidepressants should be watched closely for changes in moods or actions, especially when they first start therapy or when their dose is increased or decreased. Patients and their families should contact the doctor immediately if new symptoms develop or seem to get worse. Signs to watch for include anxiety, hostility, insomnia, restlessness, impulsive or dangerous behavior, and thoughts about suicide or dying.

    Do not take this medication if you are currently taking a drug known as a monoamine oxidase inhibitor (MAOI). MAOIs can cause a very serious reaction or even death if taken at the same time as Aplenzin. You must stop taking your MAOI at least 14 days before beginning treatment with Aplenzin. Similarly, you should wait 7 days after stopping Aplenzin before starting an MAOI. .

  • Who should not take Aplenzin?

    Do not take Aplenzin if you have a seizure disorder or epilepsy; are taking Zyban or any medication containing bupropion, such as Wellbutrin (all forms); drink alcohol and abruptly stop drinking; use sedatives or benzodiazepines and you stop using them suddenly; have taken within the last 14 days medicine for depression called a monoamine oxidase inhibitor (MAOI); have had an eating disorder such as anorexia or bulimia; are allergic to bupropion, the active ingredient in Aplenzin.
  • What should I tell my doctor before I take the first dose of Aplenzin?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Aplenzin. Also, talk to your doctor about your complete medical history, especially if you have a history of kidney or liver problems, eating disorders, head injury, seizure disorder, or tumor in the spine or nervous system. Tell your doctor if you have had a heart attack, heart problems, high blood pressure, or if you are diabetic and you are taking insulin or other medicines to control blood sugars. If you drink a lot of alcohol, or you abuse prescription medicines or street drugs, you should not take Aplenzin.
  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: The usual dose is 348 milligrams taken once daily in the morning.

  • How should I take Aplenzin?

    Take Aplenzin as prescribed by your doctor. Do not chew or crush the tablet. You must swallow the tablet whole. Take Aplenzin at the same time each day. Take your doses at least 24 hours apart. Aplenzin can be taken with or without food.
  • What should I avoid while taking Aplenzin?

    Do not drink a lot of alcohol while taking Aplenzin. If you usually drink a lot of alcohol, talk with your doctor before suddenly stopping. Do not drive a car or use heavy machinery until you know how Aplenzin affects you as it may impair your ability to perform these tasks.
  • What are possible food and drug interactions associated with Aplenzin?

    Acute toxicity of buproprion is enhanced by the MAOI phenelzine. Taking Aplenzin with agents that lower seizure threshold should be done with caution (antipsychotics, antidepressants, theophylline, systemic steroids, etc). There is increased risk of adverse events while using Aplenzin in patients using amantadine and levodopa.
  • What are the possible side effects of Aplenzin?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: agitation, fast heartbeat, muscle pain, ringing in the ears, skin rash, sore throat, stomach pain, sweating, urinating more often, weight loss

    When taking Aplenzin, some people may develop more serious side effects such as seizures; high blood pressure; unusual thoughts and behavior including delusions (believing you are someone else), hallucinations (seeing or hearing things that are not there), paranoia (feeling that people are against you); and allergic reactions (signs of severe allergic reactions may include hives, difficulty breathing, and swelling of the throat). If any of these events occur, seek immediate medical attention.

    If you have nausea, take your medicine with food. If you have trouble sleeping, do not take your medicine too close to bedtime.

  • Can I receive Aplenzin if I am pregnant or breastfeeding?

    Aplenzin should be avoided during pregnancy and breastfeeding. Talk with your doctor before taking this drug if you are pregnant, plan to become pregnant, or are breastfeeding.
  • What should I do if I miss a dose of Aplenzin?

    Wait and take your next tablet at the regular time if you miss a dose. Never take an extra tablet to make up for the dose you forgot.
  • How should I store Aplenzin?

    Store at room temperature out of direct light.