Generic Name: Apomorphine

  • What is Apokyn?

    Apokyn is a medicine used to treat loss of control of body movements in people with advanced Parkinson's disease. This condition is also called "off" episodes. Apokyn can help to improve your ability to control your muscle stiffness, slow movements, and difficulty starting movements when it is used during an "off" episode. This may help you walk, talk, or move around easier. Apokyn is administered subcutaneously (just below the skin).

  • What is the most important information I should know about Apokyn?

    Apokyn can cause heart problems. Tell your doctor immediately if you experience shortness of breath, fast heartbeat, or chest pain.

    Apokyn can also increase your risk of falling and can cause or worsen dyskinesias (sudden uncontrolled movements).

    Apokyn can lower your blood pressure and cause dizziness. This effect usually happens when you start Apokyn treatment or when the dose is increased. You may experience symptoms of nausea, fainting, and sometimes sweating. Do not get up too fast from sitting or after lying down, especially if you have been sitting or lying down for a long period of time.

    Apokyn can cause sleepiness or falling asleep during the day without warning while you are doing everyday activities (such as talking, eating, or driving a car). Tell your doctor if you experience any of these symptoms. Do not drive a car, operate machinery, or do anything that might put you at risk of getting hurt until you know how Apokyn affects you.

    Apokyn can cause severe nausea and vomiting. Your doctor may prescribe another medicine to lessen these symptoms.

    Apokyn can cause or worsen mental or psychotic problems. Tell your doctor if you experience hallucinations (seeing or hearing things that are not real), confusion, excessive suspicion, aggressive behavior, agitation, delusional beliefs (believing things that are not real), disorganized thinking, feeling of depression, new or increased gambling urges, increased sexual urges, or other intense urges.

    Apokyn can cause injection-site reactions, such as soreness, redness, bruising, and itching. Change the injection site with each injection, and put ice on the injection site before and after injections to help lower these effects.

  • Who should not take Apokyn?

    Do not use Apokyn if you are allergic to it or any of its ingredients, or with certain medicines used for nausea and vomiting called 5HT3 antagonists or blockers (such as ondansetron, granisetron, dolasetron, palonosetron, or alosetron).

  • What should I tell my doctor before I take the first dose of Apokyn?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Apokyn. Also, talk to your doctor about your complete medical history, especially if you have or had dizziness; fainting spells; low blood pressure; asthma; liver, kidney, or heart problems; stroke or other brain or mental problems; if you drink alcohol; or are pregnant, plan to become pregnant, or are breastfeeding.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: Your doctor will prescribe the appropriate dose for you based on your condition.

    If you have kidney impairment, your doctor will adjust your dose appropriately.

  • How should I take Apokyn?

    Use Apokyn exactly as prescribed by your doctor.

    Choose an injection site on your stomach area, upper arm, or upper leg.

    Change your injection site each time you use Apokyn.

    Your doctor will show you and/or your caregiver how to inject Apokyn, as well as how to properly dispose syringes and needles. Please review the instructions that came with your prescription on how to properly use Apokyn.

  • What should I avoid while taking Apokyn?

    Do not inject Apokyn into an area of skin that is sore, red, infected, or damaged.

    Do not drink alcohol or take medicines that make you sleepy while you are using Apokyn.

    Do not drive a car, operate machinery, or do anything that might put you at risk of getting hurt until you know how Apokyn affects you.

    Do not change your body position too fast. Get up slowly from sitting or lying.

    Do not reuse needles.

  • What are possible food and drug interactions associated with Apokyn?

    If Apokyn is used with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Apokyn with the following: 5HT3 antagonist, certain antipsychotics, or certain blood pressure/heart medications.

  • What are the possible side effects of Apokyn?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: allergic reactions, chest pain, dizziness, drowsiness, dyskinesias, flushing, hallucinations, increased sweating, nausea, paleness, runny nose, swelling, vomiting, yawning

  • Can I receive Apokyn if I am pregnant or breastfeeding?

    The effects of Apokyn during pregnancy and breastfeeding are unknown. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of Apokyn?

    If you miss a dose of Apokyn, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

  • How should I store Apokyn?

    Store at room temperature.