Generic Name: Rosiglitazone maleate and glimepiride

  • What is Avandaryl?

    Avandaryl contains 2 medicines: rosiglitazone maleate (Avandia) and glimepiride (Amaryl). Avandaryl is used for the treatment of type 2 diabetes mellitus in conjunction with diet and exercise. Glimepiride can help your body release more of its own insulin. Rosiglitazone can help your body respond better to the insulin made in your body. Type 2 diabetes occurs when there is a buildup of sugar in the blood, which may lead to serious health conditions.
  • What is the most important information I should know about Avandaryl?

    Full diabetic therapy should include diet and weight management, through proper eating habits and exercise.

    Rosiglitazone, one of the medicines in Avandaryl, can cause heart failure or make it worse. After starting Avandaryl therapy and after dose increases, your doctor should follow up with you carefully to see if you develop any signs and symptoms of heart failure. You should not use Avandaryl if you have severe heart failure.

  • Who should not take Avandaryl?

    Do not take Avandaryl if you are allergic/have had an allergic reaction to any of its ingredients.

    Do not take Avandaryl if you have had diabetic ketoacidosis; this condition should be treated with insulin.

    Certain patients with heart failure should not start taking Avandaryl.

    You should not take this medication if you have type 1 diabetes.

    This medication is not recommended for children under the age of 18.

  • What should I tell my doctor before I take the first dose of Avandaryl?

    Talk to your doctor about all of your medical conditions, especially if you have heart, liver or kidney problems, have a diabetic eye condition called macular edema (swelling in the back of the eye), are menopausal, pregnant or planning to become pregnant, or are breastfeeding. Also, keep your doctor informed of all prescription, over-the-counter, and herbal medications you are taking.
  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: The usual starting dose of Avandaryl is 4 milligrams (mg)/1 mg or 4 mg/2 mg once daily.

  • How should I take Avandaryl?

    Take the recommended dose orally, with your first meal of the day.

    Test your blood sugar regularly as told by your doctor.

    It is important to stay on your recommended diet, lose excess weight, and get regular exercise while taking Avandaryl.

  • What should I avoid while taking Avandaryl?

    Inform your doctor if you get sick, injured, or have surgery while on Avandaryl. This drug may not properly control your blood sugar levels during these times.
  • What are possible food and drug interactions associated with Avandaryl?

    Avandaryl may react with thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid sympathomimetics, and isoniazid, and produce hyperglycemia (high blood sugar).

    Concurrent use with oral miconazole and oral hypoglycemic agents may lead to hypoglycemia (low blood sugar).

    Inhibitors of CYP2C8 such as gemfibrozil may increase the effects of Avandaryl and this may lead to hypoglycemia and other side effects. Inducers of CYP2C8 such as rifampin may decrease how Avandaryl works in your body.

  • What are the possible side effects of Avandaryl?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: cold-like symptoms, abnormal ovulation, dizziness, fractures (usually in the hand, upper arm, or foot) in females, heart problems, liver or kidney problems, low or high blood sugar, low red blood cell count (anemia), swelling, weight gain

  • Can I receive Avandaryl if I am pregnant or breastfeeding?

    Avandaryl should not be used during pregnancy. It is recommended to have a stable blood sugar level during pregnancy; talk with your doctor about beginning insulin therapy if you are pregnant or planning to become pregnant.
  • What should I do if I miss a dose of Avandaryl?

    If you miss a dose of Avandaryl, take it as soon as you remember. If it is already time for your next dose, do not take double.
  • How should I store Avandaryl?

    Avandaryl should be stored in its original container at room temperature.