Avinza

Generic Name: Morphine

  • What is Avinza?

    Avinza is a formulation of morphine sulfate intended for once-daily administration to relieve moderate to severe chronic (long-term) pain that requires continuous, around-the-clock opioid therapy for a long period of time.

  • What is the most important information I should know about Avinza?

    Avinza is a drug of potential dependence and abuse. Do not take more than prescribed.

    Avinza should be taken whole. Do not chew, crush, cut, or dissolve the contents of the capsule.

    Do not take Avinza with alcohol or medications that contain alcohol in their formulation, as this may lead to potentially fatal doses of morphine sulfate.

  • Who should not take Avinza?

    Do not take Avinza if you have a hypersensitivity to it or any of its ingredients or to similar drugs.

    Patients with respiratory depression, acute or severe asthma, or impairment of the small intestines (paralytic ileus) should not be given this drug.

  • What should I tell my doctor before I take the first dose of Avinza?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Avinza. Also, talk to your doctor about your complete medical history, especially if you have a history of dependence of substance abuse, have respiratory depression, low blood pressure, blocked intestines, liver or kidney problems, biliary tract disease (including acute pancreatitis, which is inflammation of the pancreas), Addison's disease, low thyroid levels, prostate problems or urethral stricture (narrowing of the urethra, the tube that connects from the bladder to the genitals to lead urine out of your body). Also, talk to your doctor if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: Dosage is individualized for each patient, based on your weight and evaluation by your doctor. Avinza is intended to be given once daily in the morning.

  • How should I take Avinza?

    Take the once-daily capsules whole in the morning. Do not chew, crush, cut, or dissolve the contents of the capsule.

    Avinza can be taken with or without food. If you have trouble swallowing the capsules, you may open them and sprinkle all of the beads on a small amount of applesauce just before swallowing. Make sure to swallow the beads whole.

    Do not stop taking Avinza abruptly; if you no longer need to take Avinza, the dose must be lowered slowly.

  • What should I avoid while taking Avinza?

    Avoid alcohol or products containing alcohol in their formulation.

    Do not drive, operate any machinery, or participate in any other possibly dangerous activities while taking Avinza.

  • What are possible food and drug interactions associated with Avinza?

    If Avinza is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Avinza with the following: central nervous system depressants, sedatives, sleep medications, general anesthetics, drugs to prevent nausea and vomiting, phenothiazines, tranquilizers, alcohol, muscle relaxants, painkillers, cimetidine, and monoamine oxidase (MAO) inhibitors such as the antidepressants phenelzine and selegiline.

  • What are the possible side effects of Avinza?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: constipation, nausea, drowsiness, vomiting, itching, skin rash, headache, abdominal pain, rash, sweating, loss of appetite, dizziness, insomnia, anxiety, fever, urinary retention, depression, sexual dysfunction

  • Can I receive Avinza if I am pregnant or breastfeeding?

    Avinza should not be used during pregnancy unless your doctor knows you are pregnant and specifically recommends its use. Due to the potential harm to the baby, consult with your doctor if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of Avinza?

    If you miss a dose, take it as soon as you remember. If it is close to the time of your next dose (next day), skip it and resume your scheduled dose. Do not take two doses at once.

  • How should I store Avinza?

    Store at room temperature in a tight, light-resistant container and away from children. Protect from theft.

Meet the Pharmacists

I'm Shereen A. Gharbia, PharmD. Welcome to PDR Health!

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