What is Axert?Axert is used to treat migraine headaches in adults and adolescents 12-17 years old. It shortens the duration of the headache but will not prevent attacks.
What is the most important information I should know about Axert?Axert should only be used during a migraine attack. Do not attempt to prevent migraines with this drug, and do not use it for other types of headaches.
In rare cases, medications similar to Axert have caused heart attack, stroke, and certain types of ischemia (restricted blood flow to an area). Call your doctor immediately if you experience chest pain, shortness of breath, sudden numbness or weakness on one side of the body, trouble speaking or seeing, loss of balance, bloody diarrhea, or stomach pain.
If you are at risk for stroke or heart disease, your doctor may perform cardiovascular tests to be sure it is safe for you to take this medication. Axert can also increase blood pressure, especially in people with kidney problems and the elderly. Your doctor will monitor you closely to make sure your blood pressure stays at a safe level.
Call your doctor right away if you are itchy or get a rash after taking Axert; you may be having an allergic reaction.
Axert can cause a reaction known as serotonin syndrome, which can be life-threatening. This reaction is more likely to occur when Axert is combined with certain antidepressants known as selective serotonin reuptake inhibitors (SSRIs) and selective norepinephrine reuptake inhibitors (SNRIs). Tell your doctor immediately if you develop any of the following: agitation, fast heartbeat, high or low blood pressure, fever or sweating, tight muscles, hallucinations, difficulty walking, nausea, vomiting, or diarrhea.
Who should not take Axert?Do not take Axert if you are allergic to any of its ingredients, or if you have a history of heart disease, uncontrolled high blood pressure, or hemiplegic migraine (a rare form of migraine with symptoms that can resemble a stroke, weakness of one half of the body, or seizures).
What should I tell my doctor before I take the first dose of Axert?Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Axert. Also, talk to your doctor about your complete medical history, especially if you have a history of depression and are taking antidepressants, if you are allergic to sulfa drugs, or if you are being treated for a fungal infection. You should also tell your doctor if you have a history of high blood pressure, chest pain, shortness of breath, liver or kidney problems, or heart disease or risk factors for heart disease (such as diabetes, high cholesterol). Inform your doctor if you are pregnant, plan to become pregnant, or are breastfeeding.
What is the usual dosage?The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.
Adults and adolescents 12-17 years: The usual dose to treat an attack is one tablet containing either 6.25 milligram (mg) or 12.5 mg; each dose should be separated by at least 2 hours. The maximum recommended dose is 25 mg a day.
How should I take Axert?When you have a migraine headache, take Axert as directed by your doctor. If your headache comes back after your first dose, you may take a second dose 2 or more hours after the first dose. However, if you do not experience any pain relief after a first dose, do not take a second dose without first checking with your doctor. Do not take more than two tablets in a 24-hour period.
What should I avoid while taking Axert?Axert may make you feel sleepy; do not drive or operate heavy machinery until you know how you react to this medication.
Check with your doctor before you take any new medicines, including prescription and nonprescription medicines and supplements. There are some medicines that you should not take within 24 hours of Axert.
What are possible food and drug interactions associated with Axert?If Axert is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Axert with the following: sulfa drugs; monoamine oxidase (MAO) inhibitors such as phenelzine or tranylcypromine (or if it has been less than 2 weeks since you stopped taking an MAO inhibitor); ketoconazole, itraconazole, ritonavir, or erythromycin (or if it has been less than 1 week since you stopped taking one of these drugs); SSRIs (such as citalopram, escitalopram, paroxetine, fluoxetine, olanzapine/fluoxetine, sertraline, and fluvoxamine); and SNRIs (such as duloxetine and venlafaxine).
Do not take Axert within 24 hours of using another migraine or headache drug, including triptans and ergotamines such as the following: almotriptan, dihydroergotamine, ergotamine, frovatriptan, methysergide, naratriptan, rizatriptan, sumatriptan, and zolmitriptan.
What are the possible side effects of Axert?Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.
Side effects may include: dry mouth, headache, nausea, sleepiness, tingling or burning feeling
Can I receive Axert if I am pregnant or breastfeeding?The effects of Axert during pregnancy are unknown, and it may pass into breast milk. Talk to your doctor if you are pregnant, plan to become pregnant, or are breastfeeding.
What should I do if I miss a dose of Axert?Axert should only be taken when needed. It should not be taken on a regular basis.
How should I store Axert?Store at room temperature away from heat, light, and moisture.
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