What is Azilect?Azilect is indicated for the treatment of Parkinson's disease (PD). It can be taken alone in early stage PD, or with levodopa/carbidopa and other PD medications when more relief is needed. Azilect works by blocking the breakdown of dopamine in the brain. Azilect belongs to a group of drugs known as MAO inhibitors.
What is the most important information I should know about Azilect?When taking Azilect, avoid foods and beverages high in tyramine (see "What are possible food and drug interactions associated with this medication?"), as they may cause a dangerous increase in blood pressure.
All patients are advised to monitor for melanoma (skin cancer)
Who should not take Azilect?If you have moderate to severe liver disease or a tumor of the adrenal gland, you should not take Azilect. You should not take Azilect if you are taking certain medications (see "What are possible food and drug interactions associated with this medication?") frequently, but be sure to see a dermatologist on a regular basis.
What should I tell my doctor before I take the first dose of Azilect?Always tell your doctor about all the prescription, over-the-counter, and herbal medicines you are taking, especially antidepressants and ciprofloxacin. Talk to your doctor about your complete medical history, especially if you are pregnant, planning to become pregnant, or are nursing. Also, tell your doctor if you are planning to have surgery.
What is the usual dosage?The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.
Adults: Azilect should be administered as 1 milligram (mg) once a day if taken alone. For use with another drug such as levodopa/carbidopa, the initial dose is 0.5 mg once a day, and may be increased by your doctor to 1 mg once a day.
How should I take Azilect?Azilect should be taken once daily with or without food. Avoid tyramine-rich foods, beverages, or dietary supplements and amines (from over-the-counter cough/cold medicines) to prevent a possibly dangerous rise in blood pressure called a hypertensive crisis.
What should I avoid while taking Azilect?When taking Azilect, you should not have elective surgery requiring general anesthesia, and should not receive cocaine or other local anesthesia that contains ingredients that could raise blood pressure. Avoid certain foods, beverages, dietary supplements, and cold remedies to prevent a possibly dangerous rise in blood pressure called a hypertensive crisis.
What are possible food and drug interactions associated with Azilect?Azilect should not be taken with meperidine as it could possibly result in a serious reaction such as coma or death. Azilect should also not be taken with tramadol, methadone, propoxyphene, dextromethorphan, St. John's wort, mirtazapine, or cyclobenzaprine.
Monoamine oxidase inhibitors (MAOIs), amphetamines, cold medicines containing decongestants and weight-reducing medications containing pseudoephedrine, phenylephrine, phenylpropanolamine, or ephedrine should not be taken with Azilect to avoid dangerous increases in blood pressure.
Avoid foods and beverages high in tyramine, such as aged cheeses, air-dried meats, pickled herring, yeast extract, aged red wines, tap or draft beers, sauerkraut, and soy sauce. These foods, when consumed during therapy with Azilect, may cause dangerous increases in blood pressure.
What are the possible side effects of Azilect?Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.
Side effects may include: headache, indigestion, and joint pain
Side effects when taken with levodopa may include: accidental injury, constipation, dry mouth, joint pain, low blood pressure when standing, nausea, rash, sleepiness, uncontrolled movements, vomiting, weight loss
Can I receive Azilect if I am pregnant or breastfeeding?The effects of Azilect on pregnancy and nursing are unknown. Talk with your doctor if you are pregnant, planning to become pregnant, or are nursing.
What should I do if I miss a dose of Azilect?If a dose is missed, just continue on your normal schedule. Do not take 2 doses of Azilect at once.
How should I store Azilect?Store at room temperature.