Generic Name: Busulfan

  • What is Busulfex?

    Busulfex is a medicine used in combination with cyclophosphamide to prepare your body before bone marrow or cell transplantation for chronic myelogenous leukemia. Busulfex is administered intravenously (through a vein in your arm).

  • What is the most important information I should know about Busulfex?

    Busulfex will cause a severe decrease in the production of blood cells, including white blood cell, red blood cell, and platelet (type of blood cells that form clots to help stop bleeding) counts. Your doctor will monitor your blood cell counts regularly during your treatment and until recovery is achieved.

    Busulfex can increase your risk of developing cancer.

    Busulfex can cause seizures and liver, heart, or severe lung problems. Your doctor will monitor you during your treatment.

  • Who should not take Busulfex?

    Your doctor will not administer Busulfex to you if you are allergic to it or any of its ingredients.

  • What should I tell my doctor before I take the first dose of Busulfex?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Busulfex. Also, talk to your doctor about your complete medical history, especially if you have a history of blood disorders; head trauma; heart problems; kidney, liver, or lung disease; seizures; or are pregnant, plan to become pregnant, or are breastfeeding.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: Your doctor will prescribe and administer the appropriate dose for you based on your weight.

  • How should I take Busulfex?

    Your doctor will administer Busulfex to you.

  • What should I avoid while taking Busulfex?

    Do not miss your follow-up appointments with your doctor.

    Do not become pregnant while you are receiving Busulfex treatment.

  • What are possible food and drug interactions associated with Busulfex?

    If Busulfex is used with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to tell your doctor if you are taking any of the following prior to treatment with Busulfex: acetaminophen, itraconazole, or phenytoin.

  • What are the possible side effects of Busulfex?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: allergic reactions; back pain; blood clots; chest pain; chills; constipation; cough; depression; dizziness; dry mouth; fever; headache; high blood pressure; increased heart rate; inflammation at the injection site; itching; low calcium, magnesium, and potassium levels; lung disease; nausea; pain; rash; severe blood disorders; sleeplessness; stomach enlargement; swelling; vomiting; weakness

  • Can I receive Busulfex if I am pregnant or breastfeeding?

    Busulfex may cause harm to your unborn baby if you receive it while pregnant. The effects of Busulfex while breastfeeding are unknown. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of Busulfex?

    Do not miss your follow-up appointments with your doctor.

  • How should I store Busulfex?

    Your doctor will store this medication for you.