Generic Name: Buprenorphine

  • What is Butrans?

    Butrans is a skin patch used to treat moderate to severe chronic pain that continues around-the-clock and is expected to last for a long period of time.

  • What is the most important information I should know about Butrans?

    Butrans can be a target for people who abuse prescription medicines or street drugs. Prevent theft, misuse, and abuse. Keep Butrans in a safe place to protect from being stolen. Never give Butrans to anyone else, even if they have the same symptoms you have. It may harm them or even cause death. Selling or giving away this medicine is against the law.

    Keep Butrans in a safe place away from children. Accidental use by a child is a medical emergency and can result in death. If a child accidentally uses Butrans, get emergency help right away.

    Butrans is not for pain that you only have once in while ("as needed") or is expected to last for only a short time, or pain due to surgery.

    Serious and life-threatening breathing problems can happen with Butrans, especially during the first 24-72 hours after you apply a new patch. This can happen because of an overdose or if the dose you are using is too high for you.

    Call your doctor right away or get emergency medical help if you have trouble breathing or changes in breathing, unusual deep "sighing" breathing, slow or shallow breathing, new or unusual snoring, slow heartbeat, severe sleepiness, cold and clammy skin, feel faint, dizzy, confused, or cannot think, walk, or talk normally. Call your doctor right away if you have any swelling or blistering around a patch site.

    Do not expose Butrans to direct heat as this may cause too much of the medicine to pass into your body, which can lead to overdose and death. Keep Butrans away from heating pads, electric blankets, heaters, tanning lamps, saunas, hot tubs, heated waterbeds, hot bath, or when sunbathing.

    Do not use Butrans if the seal on the protective pouch is broken or if the patch is cut, damaged, or changed. Do not cut the patch.

    You should not take Butrans if you already take a monoamine oxidase inhibitor (MAOI) or within 14 days after you stop taking an MAOI.

  • Who should not take Butrans?

    Do not use Butrans if you have trouble breathing, severe asthma or lung problems, a bowel blockage called paralytic ileus, or are allergic to buprenorphine or any of the ingredients in Butrans.

  • What should I tell my doctor before I take the first dose of Butrans?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Butrans. Also, talk to your doctor about your complete medical history, especially if you have trouble breathing or lung problems, a heart problem called long QT syndrome (or a family history of it), head injury or brain problems, low blood pressure, liver or kidney problems, hepatitis B or hepatitis C, convulsions or seizures, severe scoliosis (curving of the spine), thyroid problems, prostate problems or trouble urinating, adrenal gland problems (such as Addison's disease), a past or present drinking problem or alcoholism (or a family history of it), mental problems including major depression or hallucinations, past or present drug abuse or addiction problem (or a family history of it), are breastfeeding or plan to breastfeed.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: Butrans patch comes in three strengths. Each Butrans patch has the strength listed on the patch (5 micrograms (mcg) per hour, 10 mcg per hour, or 20 mcg per hour). Your doctor will prescribe the patch that is right for you.

    Each Butrans patch is intended to be worn for 7 days.

  • How should I take Butrans?

    Apply Butrans skin patch to the upper outer arm, upper chest, upper back, or the side of the chest. These four sites (each present on both sides of the body) provide 8 possible application sites. Rotate Butrans among the 8 described skin sites. After Butrans removal, wait at least 21 days before reapplying to the same skin site.

    Apply Butrans to a hairless or nearly hairless skin site. If none are available, the hair at the site should be clipped, not shaven. Do not apply Butrans to irritated, broken, or cracked skin. If the application site must be cleaned, clean the site with water only. Do not use soaps, alcohol, oils, lotions, or abrasive devices. Allow the skin to dry before applying Butrans. If problems with adhesion of Butrans occur, the edges may be taped with first-aid tape.

    If the patch comes off and accidentally sticks to the skin of another person, take the patch off of that person right away, wash the area with clear water, and get medical care for them right away.

    After you stop using Butrans patches, flush used or unused patches down the toilet or dispose of the patches in household trash using the supplied Patch-Disposal Unit.

  • What should I avoid while taking Butrans?

    You should not drive, operate heavy machinery, or do other dangerous activities until you know how you react to this medicine. Butrans can make you sleepy and cause you to feel dizzy or lightheaded. This may affect your ability to think and react. Ask your doctor when it is okay to do these activities.

    You should not drink alcohol or use prescription or nonprescription medicines that have alcohol in them while using Butrans. Alcohol can increase your chances of having serious side effects including death.

    Do not apply Butrans more often than prescribed. Do not use more than one patch at the same time unless your doctor tells you to do so.

    Do not apply any medicine, cream, or lotion on the skin at the Butrans application site before applying the patch. This might affect how the patch sticks to the skin and how the medicine is absorbed from the patch.

    Do not stop using Butrans without first talking to your doctor. Your doctor will give you instructions on how to stop using this medicine slowly to avoid uncomfortable symptoms.

  • What are possible food and drug interactions associated with Butrans?

    If Butrans is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Butrans with the following: a medicine for abnormal heartbeats, alcohol, antianxiety medicines, antidepressants, antihistamines, antinausea medicines, MAOIs, muscle relaxants, other pain medicines, medicines that make you sleepy, or sleeping pills.

  • What are the possible side effects of Butrans?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: serious breathing problems that can be life-threatening, severe skin reactions, allergic reactions (rash, itching, and hives), swelling of your lips or tongue, wheezing, chest pain, drop in your blood pressure (feeling dizzy if you get up too fast from sitting or lying down), liver problems (yellowing of the skin or eyes, dark urine, light-colored stools, less of an appetite, and nausea), seizures, physical dependence, abuse, addiction, nausea, headache, dizziness, constipation, drowsiness, vomiting, dry mouth, itching, redness or rash at the patch site, constipation

  • Can I receive Butrans if I am pregnant or breastfeeding?

    The effects of Butrans during pregnancy are unknown. Butrans passes into your breast milk. You and your doctor should decide if you will take Butrans or breastfeed. You should not do both. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of Butrans?

    If you miss a dose of Butrans, ask your doctor or pharmacist for advice.

  • How should I store Butrans?

    Store at room temperature. Keep the patch in its unopened protective pouch until you are ready to use it.

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