Celebrex

Generic Name: Celecoxib

  • What is this medication and its most common uses?

    Celebrex is a nonsteroidal anti-inflammatory drug (NSAID) used to treat osteoarthritis, rheumatoid arthritis in adults, juvenile rheumatoid arthritis, ankylosing spondylitis (arthritis of the spine), and short-term pain. In addition, Celebrex is used to treat pain associated with menstrual periods.

  • What should I know when beginning and continuing on this medication?

    How does this medication work?

    Celebrex blocks a substance in your body that is involved in causing inflammation and pain in parts of the body where there is arthritis or injury.

    What are the beneficial effects of this medication and when should I begin to have results?

    What: Celebrex has been shown to relieve arthritis symptoms (such as joint pain, tenderness, and swelling) as well as pain associated with surgery and menstrual periods.

    When: When used for short-term and menstrual pain, Celebrex has been shown to relieve pain within 60 minutes of taking the medicine.

    How do I know it is working?

    You may feel relief in your arthritis symptoms and pain after you start taking Celebrex. This is a good indicator that the medicine is working. Your healthcare provider may ask you questions to assess how well your symptoms are controlled.

  • What are the possible side effects of this medication?

    The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

    Celebrex may increase the chance of a life-threatening heart attack or stroke. The risk of heart attack or stroke may be increased with longer use and in people who have heart disease. Call your healthcare provider right away if you develop chest pain, shortness of breath, weakness, or slurring of your speech while taking Celebrex.

    Celebrex should never be used right before or after a heart surgery called a coronary artery bypass graft (CABG).

    Celebrex can cause ulcers and bleeding in the stomach and intestines at any time during treatment. Ulcers and bleeding can be life-threatening and may happen without warning symptoms. The chance of a person getting an ulcer or bleeding increases with longer use, smoking, drinking alcohol, older age, having poor health, and if you are taking medicines called corticosteroids (such as prednisone) or blood thinners (such as warfarin). Call your healthcare provider right away if you develop stomach pain, indigestion, bloody or tarry stools, or you vomit blood while taking Celebrex.

    More common side effects may include: abdominal (stomach area) pain, diarrhea, gas, swelling, dizziness, sore throat, runny and stuffy nose, sinus pain and congestion, upper respiratory tract infection, rash.

    Less common side effects may include:

    Liver problems with symptoms such as nausea, fatigue, weakness, itching, yellowing of your skin or the whites of your eyes, right upper abdominal pain, and flu-like symptoms.

    Serious allergic reactions with symptoms such as skin rash, blisters, fever, itching, trouble breathing, or swelling of your face or throat.

    Celebrex may cause high blood pressure or worsen existing high blood pressure, or cause unexplained weight gain or swelling.

  • Who should not take this medication?

    Do not take Celebrex if you are allergic to it, any of its ingredients, or sulfonamide medications (such as trimethoprim/sulfamethoxazole or sulfisoxazole).

    Do not take Celebrex if you have had an asthma attack, hives, or other allergic reaction with aspirin or any other NSAID (such as ibuprofen or naproxen).

    Do not take Celebrex for pain right before or after heart bypass surgery.

    Do not take Celebrex if you have bleeding in your stomach or intestines.

    Do not take Celebrex during the late stages of your pregnancy.

  • What should I tell my healthcare provider before I take the first dose of this medication?

    Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Celebrex. Also, talk to your healthcare provider about your complete medical history, especially if you have asthma, high blood pressure or heart failure, kidney or liver problems, a history of ulcers or bleeding in your stomach or intestines, or if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

    Osteoarthritis and Ankylosing Spondylitis

    Adults: The recommended dose is 200 milligrams (mg) once a day or 100 mg twice a day.

    Rheumatoid Arthritis

    Adults: The recommended dose is 100-200 mg twice a day.

    Short-Term and Menstrual Pain

    Adults: The recommended starting dose is 400 mg at once, followed by 200 mg if needed on the first day. On the following days, the recommended dose is 200 mg twice a day as needed.

    Juvenile Rheumatoid Arthritis

    Children ≥2 years: Your healthcare provider will prescribe the appropriate dose for your child, based on his/her weight.

    If you have liver impairment, your healthcare provider may adjust your dose appropriately.

  • How should I take this medication?

    Take Celebrex exactly as prescribed by your healthcare provider. Do not change your dose without first talking to your healthcare provider.

    If your child cannot swallow capsules, empty the entire contents of the capsule onto a level teaspoon of cool or room temperature applesauce and have your child swallow the medicine and applesauce mixture right away with water.

  • What should I avoid while taking this medication?

    Do not take other NSAIDs in combination with Celebrex.

  • What are the possible food and drug interactions associated with this medication?

    If Celebrex is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Celebrex with the following: aspirin, certain blood pressure/heart medications (such as lisinopril or valsartan), fluconazole, lithium, warfarin, or water pills (such as furosemide or hydrochlorothiazide).

  • May I receive this medication if I am pregnant or breastfeeding?

    Do not take Celebrex if you are in the late stage of your pregnancy (≥30 weeks). The effects of Celebrex during early pregnancy are unknown. Celebrex can be found in your breast milk if you take it while breastfeeding. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of this medication?

    If you miss a dose of Celebrex, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

  • How should I store this medication?

    Store at room temperature.

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I'm Shereen A. Gharbia, PharmD. Welcome to PDR Health!

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