Cenestin

Generic Name: Conjugated Estrogens

  • What is Cenestin?

    This medication is used by women after menopause to reduce hot flashes, and to treat moderate to severe dryness, itching, and burning in and around the vagina. Cenestin contains a mixture of synthetic estrogens made from a plant source. It works by replacing natural estrogens in a woman who can no longer produce enough estrogen.

  • What is the most important information I should know about Cenestin?

    Estrogens increase the chances of getting cancer of the uterus. Report any unusual vaginal bleeding right away while you are taking estrogens. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Your healthcare provider should check any unusual vaginal bleeding to find out the cause.

    Do not use estrogens with or without progestins to prevent heart disease, heart attacks, or strokes. Using estrogens with or without progestins may increase your risk of heart attack, stroke, breast cancer, and blood clots.

    Using estrogens with progestins may increase your risk of dementia. You and your healthcare provider should talk regularly about whether you still need treatment with Cenestin.

  • Who should not take Cenestin?

    Do not start taking Cenestin if you have unusual vaginal bleeding, a history of certain cancers, blood clots, or liver problems, or if you have had a stroke or heart attack in the past year. Also, do not take Cenestin if you are allergic to Cenestin or any of its ingredients, and if you think you may be pregnant.

  • What should I tell my doctor before I take the first dose of Cenestin?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Cenestin. Also, talk to your doctor about your complete medical history, especially if you have asthma, seizures, migraine, endometriosis, lupus, have problems with your heart, liver, thyroid, or kidneys, have high calcium levels in your blood, are going to have surgery or will be on bedrest, or if you plan on becoming pregnant or are breastfeeding.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    You should be started at the lowest dose. Talk to your healthcare provider about how well that dose is working for you. Estrogens should be used only as long as needed. You and your healthcare provider should talk regularly (for example every 3-6 months) about whether you still need treatment with Cenestin.

    Moderate to Severe Vasomotor Symptoms (such as hot flashes)

    Adults: The recommended starting dose is 0.45 milligrams (mg)/day. The dose may be gradually increased up to 1.25 mg/day.

    Vulvar and Vaginal Atrophy

    Adults: The recommended dose is 0.3 mg/day.

  • How should I take Cenestin?

    Take one Cenestin tablet by mouth daily. Take Cenestin at the same time each day.

  • What should I avoid while taking Cenestin?

    The use of Cenestin increases the chance of having a cardiovascular event such as a heart attack, stroke, and blood clots in the veins or lungs. Avoid the use of tobacco products (eg, smoking) while you are taking Cenestin since their use increases the likelihood of one of these events occurring.

  • What are possible food and drug interactions associated with Cenestin?

    If Cenestin is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Cenestin with the following: carbamazepine, clarithromycin, erythromycin, itraconazole, ketoconazole, levothyroxine, phenobarbital, rifampin, ritonavir, or St. John's wort.

    Grapefruit juice may increase the levels of estrogen in the body and result in side effects.

  • What are the possible side effects of Cenestin?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: bloating, breast pain, depression, diarrhea, dizziness, gas, hair loss headaches, increased/decreased interest in sex, infection, irregular vaginal bleeding or spotting, nausea, nervousness, sleeplessness, sore throat, stomach cramps, vomiting, weakness, weight changes

  • Can I receive Cenestin if I am pregnant or breastfeeding?

    Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

    Estrogens are not indicated for use during pregnancy or the immediate postpartum (after birth) period. Do not use Cenestin if you are breastfeeding a baby.

  • What should I do if I miss a dose of Cenestin?

    If you miss a dose, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your normal schedule. Do not take two doses at the same time.

  • How should I store Cenestin?

    Store Cenestin at room temperature.

Meet the Pharmacists

I'm Beth Isaac, PharmD. Welcome to PDR Health!

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