What is Ceprotin?Ceprotin is used to treat patients with severe congenital Protein C deficiency for the prevention and treatment of venous thrombosis (blood clot in a vein), and purpura fulminans (blood spots, bruising and discoloring to skin as a result of clotting of small blood vessels in the skin).
Ceprotin contains Protein C, a natural protein that is made in the liver and is present in your blood. Protein C is a part of human plasma that regulates the blood clotting (coagulation) system and prevents abnormal clot formation (thrombosis). Plasma is the liquid part of human blood.
What is the most important information I should know about Ceprotin?You could have an allergic reaction to Ceprotin. You should be aware of the early signs of allergic reactions. These include: rash, hives, itching, tightness of the chest, difficulty breathing, throat tightness, and low blood pressure. The signs and symptoms of low blood pressure can include a weak pulse, feeling lightheaded or dizzy when you stand, and possibly shortness of breath. If you experience any of these symptoms while being treated with Ceprotin, quickly stop the treatment and contact your doctor. If you experience a severe allergic reaction, including difficulty breathing and (near) fainting, quickly seek emergency treatment.
There is a risk of contracting an infectious disease since Ceprotin is made from human plasma, though the collection and manufacturing process lessens this risk. Although there are steps during the making of Ceprotin to reduce the risk of getting Hepatitis A and B, your doctor may recommend that you be vaccinated against these viruses.
There is a risk of getting infected with human parvovirus B19 (B19 virus), which can be passed to a developing fetus. Symptoms of B19 virus infection include fever, drowsiness, chills and runny nose followed about 2 weeks later by a rash and joint pain. Pregnant women should discuss this risk with their doctor.
Who should not take Ceprotin?You should not use Ceprotin unless your doctor confirms that you have severe congenital Protein C deficiency.
What should I tell my doctor before I take the first dose of Ceprotin?Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Ceprotin. Also, talk to your doctor about your complete medical history, especially if you are known to have allergic-type reactions to mouse protein or heparin, you are on a low-sodium diet, have kidney problems, or are pregnant or breastfeeding.
What is the usual dosage?The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.
Adults: An initial dose of 100-120 International Units (IU) per 2.2 pounds of body weight is recommended for acute episodes and short-term treatment. Subsequently, the dose should be adjusted to maintain a target peak Protein C activity of 100%. The recommended subsequent three doses are 60-80 IU per 2.2 pounds of body weight every 6 hours. The recommended maintenance dosage is 45-60 IU per 2.2 pounds of body weight every 6 or 12 hours.
For long-term treatment, the maintenance dosage is 45-60 IU per 2.2 pounds of body weight every 12 hours.
Your dose will vary depending upon your condition, age, and body weight. Your doctor may require blood tests to help determine the dose of Ceprotin that you should receive.
These dosing guidelines are also recommended for newborn infants and children.
How should I take Ceprotin?Ceprotin is given by intravenous administration (infusion into a vein). It is given to you under the close supervision of your doctor who is experienced in replacement therapy of coagulation factors/inhibitors and where monitoring of Protein C activity is possible.
What should I avoid while taking Ceprotin?Avoid skipping doses or doubling up on doses.
What are possible food and drug interactions associated with Ceprotin?No significant interactions have been reported at this time. However, always tell your doctor about any medicines you are taking, including over-the-counter drugs, vitamins, and herbal supplements.
What are the possible side effects of Ceprotin?Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.
Side effects may include: allergic reactions (rash and itching), lightheadedness, low blood pressure, fever, restlessness, increased sweating
Can I receive Ceprotin if I am pregnant or breastfeeding?The effects of Ceprotin during pregnancy and breastfeeding are unknown. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
What should I do if I miss a dose of Ceprotin?Your dosing schedule will be determined by your doctor. Contact your doctor if you need to reschedule an injection.
How should I store Ceprotin?Your doctor will store Ceprotin properly for you.
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