Chlorpromazine

  • What is Chlorpromazine?

    Chlorpromazine has actions at all levels of the central nervous system (CNS). It is used for the treatment of the following conditions: schizophrenia; to control nausea and vomiting; for relief of restlessness and apprehension before surgery; for acute intermittent porphyria (a rare blood disease); an adjunct in the treatment of tetanus; to control the manifestations of the manic type of bipolar disorder; and for relief of intractable hiccups.
  • What is the most important information I should know about Chlorpromazine?

    Because chlorpromazine can suppress the cough reflex, aspiration vomiting is possible.

    Chlorpromazine prolongs and intensifies the action of CNS depressants such as anesthetics, barbiturates, and narcotics.

    Use this drug with caution if you will be exposed to extreme heat, insecticides, or pesticides.

  • Who should not take Chlorpromazine?

    Do not use chlorpromazine if you have heart disease, kidney or liver problems (including cirrhosis), bone marrow depression, or if you have ever had an allergic reaction to chlorpromazine or other medications like it.

    Chlorpromazine should not be combined with, or taken within 14 days of, a type of drug known as a monoamine oxidase inhibitor (MAOI).

  • What should I tell my doctor before I take the first dose of Chlorpromazine?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with chlorpromazine. Also, talk to your doctor about complete medical history, especially if you have heart problems, heart defects, or a family history of heart problems; liver disease, including cirrhosis; kidney disease; certain eye problems such as glaucoma; and asthma, emphysema, or acute respiratory infections, particularly in children.
  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: The dose will be adjusted by your doctor according to the severity of the condition; it is important to increase the dosage until symptoms are controlled. Dosage should be increased more gradually in debilitated patients. In continued therapy, gradually reducing the dosage to the lowest effective maintenance level is recommended.

    Available dosages are 10 mg, 25 mg, 50 mg, 100 mg and 200 mg. The 100 mg and 200 mg tablets are for use in severe neuropsychiatric conditions.

    Children 6 months to 12 years: Chlorpromazine should generally not be used in pediatric patients under 6 months old. For patients with severe behavioral problems, dose is based on body weight. Your child's doctor will determine the appropriate dose. In severe behavior disorders, higher dosages (50-100 mg daily and in older children, 200 mg daily or more) may be necessary.

  • How should I take Chlorpromazine?

    Do not exceed the recommended dosage or take this medication for longer than prescribed. Follow the dosage instructions provided by your physician.
  • What should I avoid while taking Chlorpromazine?

    Chlorpromazine may impair mental and/or physical abilities, especially during the first few days of therapy. Therefore, use caution while performing activities that require alertness.

    Avoid the use of alcohol with this drug.

  • What are possible food and drug interactions associated with Chlorpromazine?

    If chlorpromazine is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining chlorpromazine with the following: blood pressure medicines, blood thinners, propranolol, seizure medicines, and thiazide diuretics such as hydrochlorothiazide.
  • What are the possible side effects of Chlorpromazine?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: drowsiness, jaundice, dizziness upon standing, spasm of the neck muscle, motor restlessness, tardive dyskinesia (a movement disorder), adverse behavioral effects, changes in vision

  • Can I receive Chlorpromazine if I am pregnant or breastfeeding?

    Safety of chlorpromazine during pregnancy has not been established. It is not recommended that the drug be taken by pregnant patients. There is evidence that chlorpromazine is excreted in the breast milk of nursing mothers.
  • What should I do if I miss a dose of Chlorpromazine?

    Take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your regular schedule. Do not take two doses at the same time.
  • How should I store Chlorpromazine?

    Store in a cool, dry place in a tightly closed, light-resistant container.