Generic Name: Clofarabine

  • What is Clolar?

    Clolar is a medicine used to treat relapsed (your leukemia comes back after treatment) or refractory (your leukemia does not respond to initial treatment) acute lymphoblastic leukemia (ALL) after two prior treatment regimens. Clolar is administered intravenously (through a vein in your arm).

  • What is the most important information I should know about Clolar?

    Clolar can cause a decrease in neutrophil (type of cell that fights infections) counts in your blood. This may increase your risk of developing an infection. Clolar can also cause low platelet (type of blood cells that form clots to help stop bleeding) counts or low red blood cell counts. Your doctor will monitor your blood cell counts before you start Clolar and regularly during your treatment. Tell your doctor if you experience easy bruising, fever, paleness of your skin, shortness of breath, skin discolorations, tiredness, or weakness.

    Clolar can cause tumor lysis syndrome, a life-threatening condition characterized by a rapid release of contents from tumor cells into your blood and causing metabolic problems, including an abnormally high levels of uric acid in your blood.

    Tell your doctor immediately if you develop a fever, rapid heartbeat, rapid breathing, shortness of breath, or low blood pressure while you are receiving Clolar. This can develop into serious conditions, such as systemic inflammatory response syndrome (SIRS) with inflammation, organ dysfunction, and organ failure.

    Clolar can cause liver problems. Your doctor will monitor your liver function while you are receiving Clolar.

    Clolar can cause harm to your unborn baby if you receive it during pregnancy. Tell your doctor immediately if you are pregnant or plan to become pregnant. If you are a man, use appropriate contraceptive measures while you are receiving Clolar.

  • Who should not take Clolar?

    Your doctor will not administer Clolar to you if you are allergic to it or any of its ingredients.

  • What should I tell my doctor before I take the first dose of Clolar?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Clolar. Also, talk to your doctor about your complete medical history, especially if you have kidney or liver impairment, bleeding problems, or are pregnant, plan to become pregnant, or are breastfeeding.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Children 1-21 years: Your doctor will administer the appropriate dose for you or your child based on the weight and height.

    If you have a severely low neutrophil count, your doctor will adjust your dose appropriately.

  • How should I take Clolar?

    Your doctor will administer Clolar to you, over 2 hours for 5 consecutive days.

    Your doctor will tell you how often you should receive Clolar.

  • What should I avoid while taking Clolar?

    Do not miss your scheduled appointments to receive Clolar.

  • What are possible food and drug interactions associated with Clolar?

    No significant interactions have been reported with Clolar at this time. However, always tell your doctor about any medicines you take, including over-the-counter medications, vitamins, and herbal supplements.

  • What are the possible side effects of Clolar?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: anxiety, decreased blood cell counts, diarrhea, fever, flushing, headache, itching, mouth sores, nausea, rash, redness or swelling of your hands or feet, tiredness, vomiting

  • Can I receive Clolar if I am pregnant or breastfeeding?

    Clolar can cause harm to your unborn baby if you receive it during pregnancy. The effects of Clolar while breastfeeding are unknown. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of Clolar?

    Contact your doctor if you miss your scheduled appointment to receive Clolar.

  • How should I store Clolar?

    Your doctor will store this medication for you.