Generic Name: Estradiol and norethindrone acetate

  • What is CombiPatch?

    CombiPatch is used after menopause to reduce moderate to severe hot flashes; treat moderate to severe dryness, itching and burning in or around the vagina; and to treat certain conditions in which a young woman's ovaries do not produce enough estrogen naturally. If you use CombiPatch only to treat your dryness, itching and burning in or around the vagina, talk with your doctor about whether a topical vaginal product would be better for you.
  • What is the most important information I should know about CombiPatch?

    Do not use estrogens and progestins to prevent heart disease, heart attacks, strokes or dementia. Using estrogens with progestins may increase your chances of experiencing a heart attack, stroke, breast cancer, blood clot, or dementia.

    Irregular bleeding may occur, particularly in the first 6 months of therapy, but generally decreases with time and often stops completely.

  • Who should not take CombiPatch?

    Do not use CombiPatch if you have had your uterus removed (hysterectomy). CombiPatch should not be used if you have unusual vaginal bleeding, a history of certain cancers, including cancer of the breast or uterus, a recent (in past year) history of stroke or heart attack, a history of blood clots or liver problems, or think you may be or know that you are pregnant.

    CombiPatch should also be avoided if you are allergic to it or any of its ingredients.

  • What should I tell my doctor before I take the first dose of CombiPatch?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking, before beginning therapy with CombiPatch. Also, talk to your doctor about your complete medical history, especially if you have had a history of cancer, kidney problems, endometriosis (severe pain and unusual bleeding during menstruation), wheezing, high blood sugar, seizures, or migraines.
  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: The recommended starting dose is 1 patch containing 0.05 milligrams (mg) estradiol and 0.14 mg norethindrone acetate applied twice a week or every 3 to 4 days. If needed, your doctor may increase your dose to a patch containing 0.05 mg estradiol and 0.25 mg norethindrone acetate.

    CombiPatch can also be used in conjunction with a 0.05 mg estradiol-only patch. The estradiol-only patch is applied twice a week for the first 14 days of a 28-day cycle, and CombiPatch is applied twice weekly for the remaining 14 days.

    If you are currently taking another form of hormone replacement therapy, you should complete the current cycle before switching to CombiPatch.

  • How should I take CombiPatch?

    Put on a new CombiPatch every 3 to 4 days, according to your doctor's instructions. It should be applied to clean, dry skin on the lower stomach; each new patch should be applied to a different area of your skin. Change the patch on the same days each week. Only one CombiPatch should be worn at any one time.

    CombiPatch can be worn during bathing, swimming, or showering. Most women find that CombiPatch seldom comes off. But if a patch should fall off, the same patch may be put on a different area of the lower abdomen (make sure you are choosing a clean, dry, lotion-free area of skin). If the patch will not stick completely to your skin, put a new CombiPatch on a different area of the lower abdomen. No matter what day this happens, go back to changing the patch on the same days each week.

  • What should I avoid while taking CombiPatch?

    Avoid exposing CombiPatch to the sun for long periods of time. Once it is in place, be sure that it is covered with clothing.

    Avoid placing the patch over skin that has cuts, a rash, or other irritations.

  • What are possible food and drug interactions associated with CombiPatch?

    If CombiPatch is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining CombiPatch with any of the following: carbamazepine, clarithromycin, erythromycin, grapefruit juice, itraconazole, ketoconazole, phenobarbital, ritonavir, St. John's wort, thyroid medications.
  • What are the possible side effects of CombiPatch?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: bloating, stomach cramps, breast pain, hair loss, headache, irregular vaginal bleeding/spotting, nausea, vomiting, yeast infection

    Symptoms of serious side effects (call your doctor immediately): breast lumps, changes in speech, changes in vision, chest pain, dizziness, faintness, pain in legs, severe headache, shortness of breath, unusual vaginal bleeding, vomiting

  • Can I receive CombiPatch if I am pregnant or breastfeeding?

    The effects of CombiPatch during pregnancy and breastfeeding are unknown. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
  • What should I do if I miss a dose of CombiPatch?

    If you are currently wearing a patch, remove it and put on a new patch in a different area of your lower stomach. Then go back to changing the patch on the same days each week.
  • How should I store CombiPatch?

    Store at room temperature.