What is Demadex?Demadex is a diuretic (water pill) used to reduce the fluid retention and swelling associated with congestive heart failure, kidney disease, and cirrhosis (scarring of the liver). It is also used to treat high blood pressure, either alone or with other medications.
What is the most important information I should know about Demadex?Demadex has been known to cause dehydration, chemical imbalances in the body, and a reduction in the volume of blood. Symptoms of these problems include dry mouth, thirst, weakness, drowsiness, restlessness, muscle pain or fatigue, low blood pressure, diminished urination, rapid heartbeat, nausea, and vomiting. If any of these symptoms develop, discontinue Demadex and contact your doctor immediately.
You should keep regular appointments with your doctor while on Demadex to monitor the potassium and other electrolytes in your blood.
Who should not take Demadex?Avoid Demadex if you have had a previous allergic reaction to the drug or to sulfonylurea drugs.
Do not take Demadex if you are unable to urinate.
What should I tell my doctor before I take the first dose of Demadex?Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Demadex. Also, talk to your doctor about your complete medical history, especially if you have liver problems, heart disease, high cholesterol, diabetes, hearing problems, or if you have allergies to Demadex or sulfonylurea medications.
What is the usual dosage?The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.
Chronic Kidney Failure
Adults: The usual starting dose is 20 milligrams (mg) once a day. If this proves inadequate, your doctor may adjust your dose as needed.
Cirrhosis of the Liver
Adults: The usual starting dose is 5 or 10 mg once a day, administered along with other medications that your doctor will prescribe. If this proves inadequate, your doctor will adjust your dose as needed.
Congestive Heart Failure
Adults: The usual starting dose is 10 mg or 20 mg once a day. If this proves inadequate, your doctor will adjust your dose as needed.
High Blood Pressure
Adults: The usual starting dose is 5 mg once a day. If your blood pressure is still too high within 4-6 weeks, your doctor may increase the dose to 10 mg once a day. If that is not sufficient, your doctor may add another drug to your treatment plan.
How should I take Demadex?Take this medication exactly as prescribed, with or without food.
What should I avoid while taking Demadex?Avoid taking Demadex with cholestyramine.
What are possible food and drug interactions associated with Demadex?If Demadex is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Demadex with the following: certain antibiotics, aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs), cholestyramine, digoxin, ethacrynic acid, lithium, and probenecid.
What are the possible side effects of Demadex?Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.
Side effects may include: headache, excessive urination, dizziness, runny nose, weakness, diarrhea, increased cough, constipation, nausea, joint pain, upset stomach, sore throat, muscle pain, chest pain, insomnia, edema (swelling), nervousness
Can I receive Demadex if I am pregnant or breastfeeding?The effects of Demadex during pregnancy and breastfeeding are unknown. Tell your doctor immediately if you are pregnant, plan to become pregnant, are breastfeeding, or plan to breastfeed.
What should I do if I miss a dose of Demadex?If you miss a dose of Demadex, take the missed dose as soon as you remember it. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.
How should I store Demadex?Store at room temperature.
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