What is this medication and its most common uses?Dexilant is a medicine known as a proton pump inhibitor (PPI) that is used to treat and maintain healing of erosive esophagitis (inflammation and ulceration of the esophagus [the tube that connects your mouth and stomach]). It is also used to treat heartburn symptoms associated with gastroesophageal reflux disease (GERD).
What should I know when beginning and continuing on this medication?How does this medication work?
Dexilant is a delayed-release medicine (releases medicine into your body at a later time from when you take it). It works by reducing the acid in your stomach.
What are the beneficial effects of this medication and when should I begin to have results?
Erosive Esophagitis: Dexilant may heal acid-related damage to the lining of the esophagus and prevent it from coming back.
GERD: By reducing stomach acid, Dexilant may relieve heartburn.
Erosive Esophagitis: Studies show Dexilant may start healing erosive esophagitis after 4 weeks of therapy.
GERD: Dexilant may leave you heartburn free for 24 hours.
How do I know it is working?
You may start to notice a reduction in the severity or frequency of your heartburn. This is a good indicator that your medication is working. Your healthcare provider will ask you questions from time to time to assess how well your heartburn is controlled and to check for improvement of your condition.
What are the possible side effects of this medication?The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.
More common side effects may include: diarrhea, stomach pain, nausea, infection, vomiting, gas.
Less common side effects may include:
Diarrhea that does not go away.
Fractures of the hip, wrist, or spine if you take multiple doses a day for long periods.
Low blood magnesium levels with symptoms such as seizures, irregular heartbeat, jitteriness, jerking movements or shaking, muscle weakness, spasms of your hands and feet, cramps or muscle aches, or spasm of your voice box.
Who should not take this medication?Do not take Dexilant if you are allergic to it or any of its ingredients.
What should I tell my healthcare provider before I take the first dose of this medication?Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Dexilant. Also, talk to your healthcare provider about your complete medical history, especially if you have low magnesium levels, any allergies, liver problems, or if you are pregnant, plan to become pregnant, or are breastfeeding.
What is the usual dosage?The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.
Treatment of Erosive Esophagitis
Adults: The recommended dose is 60 milligrams (mg) once a day for up to 8 weeks.
If you have liver impairment, your healthcare provider will adjust your dose appropriately.
Maintain Healing of Erosive Esophagitis
Adults: The recommended dose is 30 mg once a day.
Heartburn Associated with GERD
Adults: The recommended dose is 30 mg once a day for 4 weeks.
How should I take this medication?Take Dexilant exactly as prescribed by your healthcare provider.
Take Dexilant with or without food. Swallow capsules whole. Do not chew the capsules. If you have trouble swallowing Dexilant capsules, open the capsules and sprinkle the contents on a tablespoon of applesauce. Swallow the applesauce mixture right away. Do not chew the mixture or store for later use.
What should I avoid while taking this medication?Do not change your dose or stop taking Dexilant without first talking to your healthcare provider.
What are the possible food and drug interactions associated with this medication?If Dexilant is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Dexilant with the following: ampicillin, atazanavir, digoxin, ketoconazole, methotrexate, products that contain iron, tacrolimus, or warfarin.
May I receive this medication if I am pregnant or breastfeeding?The effects of Dexilant during pregnancy and breastfeeding are unknown. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
What should I do if I miss a dose of this medication?If you miss a dose of Dexilant, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.
How should I store this medication?Store at room temperature.
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