Generic Name: Glyburide

  • What is Diabeta?

    Diabeta is an oral medication used along with diet and exercise to help lower blood sugar levels in patients who have type 2 diabetes. It belongs to a class of drugs called sulfonylureas.

  • What is the most important information I should know about Diabeta?

    Treatment with Diabeta may increase the risk of death from heart and blood vessel problems compared to treatment of diabetes with diet alone or diet plus insulin. Discuss with your doctor the risks and benefits of treatment with Diabeta.

    Low blood sugar may occur. The signs and symptoms of low blood sugar (hypoglycemia), include headache, drowsiness, weakness, dizziness, fast heartbeat, sweating, tremor, and nausea.

    Loss of blood sugar control may occur when exposed to stress such as trauma, fever, infection, or surgery. Insulin use may be necessary at such a time.

    Follow diet, medication, and exercise routines closely. Changing any of them can affect blood sugar levels. Blood levels should be assessed regularly.

  • Who should not take Diabeta?

    Diabeta should not be used in patients who are allergic to the drug or its ingredients, have type 1 diabetes or diabetic ketoacidosis (a life-threatening medical emergency caused by insufficient insulin), or are treated with bosentan.

  • What should I tell my doctor before I take the first dose of Diabeta?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Diabeta. Also, talk to your doctor about your complete medical history, especially if you are pregnant, plan to become pregnant, or are breastfeeding; have kidney, liver, or thyroid disease; have a sulfa allergy; have a serious infection, illness, or injury; have glucose-6-phosphate dehydrogenase (G6PD) deficiency (lack of an enzyme responsible for the breakdown of red blood cells); or if you need surgery.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: The initial dose is 2.5-5 milligrams (mg) once a day. The dose should be increased by no more than 2.5 mg per day at weekly intervals. Your doctor will adjust the dosing as necessary.

    For patients who have kidney or liver disease, adrenal or pituitary insufficiency, and for those who are elderly, injured, or malnourished, the initial dose is 1.25 mg once a day.

  • How should I take Diabeta?

    Take Diabeta exactly as directed by your doctor. Diabeta is usually taken before breakfast or the first main meal if it is taken once a day, or before meals if it is taken multiple times each day. Patients taking more than 10 mg a day may benefit from twice-daily dosing.

  • What should I avoid while taking Diabeta?

    Avoid alcohol as it may lower blood sugar and interfere with diabetes treatment.

  • What are possible food and drug interactions associated with Diabeta?

    If Diabeta is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Diabeta with the following: angiotensin-converting enzyme (ACE) inhibitors (such as lisinopril and enalapril), aspirin, beta-blockers (such as atenolol and propanolol), blood thinners (such as warfarin), bosentan, calcium channel blockers (such as amlodipine and verapamil), chloramphenicol, clarithromycin, corticosteroids, cyclosporine, disopyramide, diuretics (such as hydrochlorothiazide), estrogens, certain antibiotics (such as levofloxacin and ciprofloxacin), fluoxetine, isoniazid, miconazole, monoamine oxidase inhibitors (such as hydralazine and linezolid), nicotinic acid, nonsteroidal anti-inflammatory drugs (NSAIDs), birth control pills, chlorpromazine, perphenazine, phenytoin, probenecid, rifampin, salicylates (such magnesium salicylate or bismuth subsalicylate), sulfa drugs (such as sulfamethoxazole), albuterol, ephedrine, or thyroid medications (such as levothyroxine).

  • What are the possible side effects of Diabeta?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: low blood sugar (symptoms are shaking, headache, cold sweats, pale and cool skin, anxiety, difficulty concentrating), abdominal fullness, allergic skin reactions such as redness and itching, heartburn, nausea

  • Can I receive Diabeta if I am pregnant or breastfeeding?

    The effects of Diabeta during pregnancy and breastfeeding are unknown. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of Diabeta?

    If you miss a dose of Diabeta, take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

  • How should I store Diabeta?

    Store at room temperature.

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I'm Shereen A. Gharbia, PharmD. Welcome to PDR Health!

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