Generic Name: Chlorpropamide

  • What is Diabinese?

    Diabinese is an oral antidiabetic medication used to treat type 2 diabetes. Diabetes occurs when the body fails to produce enough insulin or is unable to use it properly.

  • What is the most important information I should know about Diabinese?

    Always remember that Diabinese is an aid to helping to control your glucose (sugar) levels. It is not a substitute for a good diet and exercise.

    Diabinese may cause severe lowering of blood sugar (hypoglycemia). There is a greater risk of hypoglycemia if you have kidney or liver problems; are elderly, debilitated or malnourished; have adrenal or pituitary problems; don't eat enough; exercise too much; drink alcohol; or use multiple diabetes medications.

    Loss of control of blood sugar may occur when you are exposed to stress such as fever, trauma, infection, or surgery. Insulin may be necessary.

    The effectiveness of Diabinese may decrease over time from disease progression.

    Diabinese may cause hemolytic anemia (a destruction of red blood cells) in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency.

    Taking Diabinese may increase your risk of developing heart problems.

    Blood glucose levels should be assessed regularly.

  • Who should not take Diabinese?

    You should not take Diabinese if you have ever had an allergic reaction to it.

    Do not take Diabinese if you are suffering from diabetic ketoacidosis (a life-threatening medical emergency caused by insufficient insulin and marked by excessive thirst, nausea, fatigue, and pain below the breastbone).

    Remember, Diabinese is used to help treat type 2 diabetes. If you have type 1 diabetes, do not use this medication.

  • What should I tell my doctor before I take the first dose of Diabinese?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Diabinese. Also, talk to your doctor about your complete medical history, especially if you have heart problems, G6PD deficiency, or diabetic ketoacidosis.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: Usually, an initial daily dose of 250 milligrams (mg) is recommended for stable, middle-aged, non-insulin-dependent diabetics. After 5-7 days, your doctor may adjust this dosage in increments of 50-125 mg every 3-5 days to achieve the best benefit. People with mild diabetes may respond well to daily doses of ≤100 mg, while those with severe diabetes may require 500 mg daily. Maintenance doses >750 mg are not recommended.

    Older adults and people who are malnourished, debilitated, or have kidney or liver problems usually take an initial dose of 100-125 mg.

  • How should I take Diabinese?

    Diabinese is usually taken as a single daily dose each morning with breakfast. However, if this upsets your stomach, you may be instructed to take Diabinese in smaller doses throughout the day.

  • What should I avoid while taking Diabinese?

    Avoid alcohol; excessive alcohol consumption can cause low blood sugar and a disulfiram-like reaction (a drug-induced reaction that produces symptoms such as breathlessness, chest tightness, nausea, vomiting, and facial flushing).

  • What are possible food and drug interactions associated with Diabinese?

    If Diabinese is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important that you consult with your doctor before taking Diabinese with the following: alcohol, barbiturates such as phenobarbital, beta-adrenergic blocking agents such as propranolol and metoprolol, calcium channel blockers such as diltiazem and verapamil, chloramphenicol, corticosteroids such as prednisone, coumarins such as warfarin, estrogens, isoniazid, miconazole, monoamine oxidase inhibitors such as phenelzine, nicotinic acid, nonsteroidal anti-inflammatory drugs such as ibuprofen and naproxen, oral contraceptives, phenothiazines such as chlorpromazine, phenytoin, probenecid, salicylates such as aspirin, sulfonamides such as sulfisoxazole, sympathomimetics such as albuterol, thiazides and other diuretics such as hydrochlorothiazide and furosemide, and thyroid products.

  • What are the possible side effects of Diabinese?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: hypoglycemia, gastrointestinal disturbances (eg, nausea, diarrhea, vomiting, hunger, loss of appetite), itching, skin reactions, sun reaction (photosensitivity reaction), decreased white blood cell levels (leukopenia), failure of bone marrow to make white blood cells (agranulocytosis)

  • Can I receive Diabinese if I am pregnant or breastfeeding?

    The effects of Diabinese during pregnancy are not clear. Diabinese should only be given to a pregnant woman if the benefits clearly outweigh the risks. If you are pregnant or plan to become pregnant, inform your doctor immediately. Since studies suggest the importance of maintaining normal blood sugar (glucose) levels during pregnancy, your physician may prescribe injected insulin.

    To minimize the risk of hypoglycemia in newborn babies, Diabinese, if prescribed during pregnancy, should be discontinued at least 1 month before the expected delivery date.

    Since Diabinese appears in breast milk, it is not recommended for nursing mothers.

  • What should I do if I miss a dose of Diabinese?

    If you miss a dose of Diabinese, take the missed dose as soon as you remember it. However, if it is almost time for your next dose, skip the missed dose and return to your regular dosing schedule. Do not take two doses at once.

  • How should I store Diabinese?

    Store at room temperature.

Meet the Pharmacists

I'm Shereen A. Gharbia, PharmD. Welcome to PDR Health!

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