Generic Name: Adapalene

  • What is Differin?

    Differin is used to treat acne.

  • What is the most important information I should know about Differin?

    Differin makes your skin more sensitive to sunlight. While using this product, keep your exposure to the sun at a minimum, and protect yourself with sunscreen and clothing. Never apply Differin to sunburned skin.

  • Who should not take Differin?

    Do not use Differin if you are sensitive to adapalene or any other components of the cream or gel.

  • What should I tell my doctor before I take the first dose of Differin?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Differin. Also, talk to your doctor about your complete medical history, especially if you have eczema (an inflammation or irritation of the skin); or sunburned skin.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults and children ≥12 years: The usual dose is a thin film applied over the acne-affected area just before bedtime.

  • How should I take Differin?

    Differin should be applied once a day at bedtime. Wash the affected areas, pat dry, then apply a thin layer of the gel or cream. Avoid contact with your eyes, lips, mouth, and nostrils.

    Use Differin exactly as prescribed. Applying excessive amounts or using the gel or cream more than once a day will not produce better results and may cause severe redness, peeling, and discomfort. If you have an allergic reaction or severe irritation, stop using the medication and call your doctor.

    In the first few weeks of treatment, your acne may actually seem to get worse. This just means the medication is working. Continue using the product. It can take as much as 8-12 weeks before you start to see improvement.

  • What should I avoid while taking Differin?

    Remember that Differin increases sensitivity to sunlight. Protect yourself from overexposure, such as using sunscreen or wearing a hat, when exposure cannot be avoided. Wind and cold weather may also be irritating.

    Do not apply Differin to cuts, abrasions, eczema, or sunburned skin. Avoid contact with your eyes, lips, mouth, and nostrils. Do not use hair removers or waxes on treated skin due to the potential for skin erosions.

    Do not use more than the recommended amount of Differin and do not apply it more than once daily as this will not produce faster results, but may increase irritation.

    Moisturizers may be used if necessary; however, products containing alpha hydroxy or glycolic acids should be avoided.

  • What are possible food and drug interactions associated with Differin?

    Avoid using Differin with any other product that can irritate the skin, such as medicated soaps and cleansers, soaps and cosmetics that have a strong drying effect, and products with high concentrations of alcohol, astringents, spices, and lime.

    Special caution is necessary if you have used, or are currently using, any skin product containing sulfur, resorcinol, or salicylic acid. Do not use such a product with Differin. If you have used one of these products recently, do not begin Differin treatment until the effects of the other product have subsided.

  • What are the possible side effects of Differin?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: acne flare-ups, burning, dryness, irritation, itching, redness, scaling, stinging, sunburn

  • Can I receive Differin if I am pregnant or breastfeeding?

    The effects of Differin during pregnancy and breastfeeding have not been adequately studied. Tell your doctor immediately if you are pregnant, plan to become pregnant, are breastfeeding or plan to breastfeed.

  • What should I do if I miss a dose of Differin?

    If you miss a dose of this drug, skip it. Do not take an extra dose to make up for missed doses.

  • How should I store Differin?

    Store at room temperature.

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I'm Beth Isaac, PharmD. Welcome to PDR Health!

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