What is Diflunisal?Diflunisal is a nonsteroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain and to relieve the inflammation, swelling, stiffness, and joint pain associated with rheumatoid arthritis and osteoarthritis.
What is the most important information I should know about Diflunisal?Diflunisal and other NSAIDs may increase the risk of developing serious life-threatening heart or circulation problems, such as heart attack and stroke, especially with long-term use, and may result in hospitalization and even death. These may occur without warning signs. Tell your doctor immediately if you experience chest pain, shortness of breath, or weakness.
Diflunisal and other NSAIDs can cause stomach discomfort. Rarely, serious ulcers or internal bleeding can occur without warning and result in hospitalization or even death. Tell your doctor immediately if you experience stomach pain, indigestion, or bloody vomit or stools. The risk of getting an ulcer or bleeding is greater if you also take corticosteroids or blood thinners, use NSAIDs for an extended period of time, if you smoke or drink alcohol, are older, or are in poor health.
You should have frequent checkups with your doctor if you use Diflunisal regularly. Diflunisal can cause vision problems. If you experience any changes in your vision, inform your doctor.
Who should not take Diflunisal?If you are sensitive to or have had an allergic reaction to Diflunisal, aspirin, or similar medications, or if you have had asthma attacks caused by aspirin or other drugs of this type, you should not take this medication. Make sure that your doctor is aware of any drug reactions that you have experienced.
Do not take Diflunisal for the treatment of pain associated with coronary artery bypass graft (CABG) surgery.
What should I tell my doctor before I take the first dose of Diflunisal?Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with this medication. Also, talk to your doctor about your complete medical history, especially if you have ever had any of the following: stomach ulcers or bleeding, kidney or liver problems, heart disease, or high blood pressure.
NSAIDs such as Diflunisal can hide the signs and symptoms of infection. Be sure your doctor knows about any infection you may have.
What is the usual dosage?The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.
Mild to Moderate Pain
Adults and Children ≥12 Years: Starting dose is 1,000 milligrams (mg), followed by 500 mg every 8-12 hours, depending on the individual. Your physician may adjust your dosage according to your age and weight, and the severity of your symptoms.
Osteoarthritis and Rheumatoid Arthritis
Adults and Children ≥12 Years: The usual dose is 500-1,000 mg per day in two doses of 250-500 mg. Use no more than necessary to relieve the pain. The maximum recommended dosage is 1,500 mg per day.
How should I take Diflunisal?Take Diflunisal with food, or food together with an antacid, and with a full glass of water or milk. Never take it on an empty stomach. Tablets should be swallowed whole, not chewed or crushed.
What should I avoid while taking Diflunisal?Avoid taking aspirin or any other anti-inflammatory medications while taking Diflunisal, unless your doctor tells you to do so.
Diflunisal may cause you to become drowsy or less alert; therefore, driving or operating dangerous machinery or participating in any hazardous activity that requires full mental alertness is not recommended.
What are possible food and drug interactions associated with Diflunisal?If Diflunisal is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Diflunisal with the following: acetaminophen, antacids taken regularly, aspirin, blood thinners, cyclosporine, diuretics (water pills), methotrexate, other NSAIDs, sulindac, or lithium.
What are the possible side effects of Diflunisal?Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.
Side effects may include: abdominal pain, constipation, diarrhea, dizziness, fatigue, gas, headache, inability to sleep, indigestion, nausea, rash, ringing in ears, sleepiness, vomiting
Can I receive Diflunisal if I am pregnant or breastfeeding?Diflunisal should be avoided in late pregnancy. If you are pregnant or plan to become pregnant, inform your doctor immediately. Diflunisal appears in breast milk and could affect a nursing infant. Consult your doctor before breastfeeding.
What should I do if I miss a dose of Diflunisal?If you miss a dose of this medication, skip it. Do not take an extra dose to make up for missed doses.
How should I store Diflunisal?Store at room temperature, away from dampness and moisture.
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