Generic Name: Methadone

  • What is Dolophine?

    Dolophine is a narcotic pain medication similar to morphine that is used to treat moderate-to-severe pain that is not responsive to non-narcotic pain medications. Dolophine may also be used to treat or control withdrawal symptoms in patients being treated for narcotic drug addiction.

  • What is the most important information I should know about Dolophine?

    Dolophine can cause life-threatening breathing or heart problems that can lead to death. This is more likely to occur in people who are just starting Dolophine therapy as well as in people who are switching from other narcotic pain medication. Breathing problems from Dolophine may not happen right after taking a dose; they can occur some time later, even after pain has returned.

    Dolophine can cause life-threatening heartbeat problems. This may be more common in people taking large doses of Dolophine.

    Dolophine may decrease your blood pressure when you get up too fast from sitting or lying down. This may lead to dizziness and fainting.

  • Who should not take Dolophine?

    Do not take Dolophine if you have severe asthma or lung problems, blockage or obstruction in your intestines, or if you are allergic or sensitive to any of the ingredients in Dolophine.

    Safety and effectiveness in pediatric patients <18 years have not been established.

  • What should I tell my doctor before I take the first dose of Dolophine?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Dolophine. Also, talk to your doctor about your complete medical history, especially if you have a history of drug or alcohol abuse or addiction, abdominal conditions, head injuries, kidney or liver problems, lung disease or breathing problems, are pregnant or plan to become pregnant, or are breastfeeding.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: Your doctor will prescribe the appropriate dosage for you.

  • How should I take Dolophine?

    Take Dolophine exactly as prescribed by your doctor. Do not adjust your dose or use Dolophine for longer than recommended by your doctor. Talk to your doctor about your pain. Your doctor can decide if your Dolophine dose needs to be changed.

    When starting treatment with Dolophine for narcotic drug dependence, you should be aware that your dose of methadone will "hold" for longer periods of time as treatment goes on.

  • What should I avoid while taking Dolophine?

    Do not drive, operate heavy machinery, or do other possibly dangerous activities until you know how Dolophine affects you. Dolophine can make you sleepy.

    Avoid drinking alcohol. It may increase the chance of having dangerous side effects.

    Avoid abrupt discontinuation of Dolophine if you have been taking it for an extended period of time. Your doctor may need to gradually decrease your dose of Dolophine before discontinuing therapy.

  • What are possible food and drug interactions associated with Dolophine?

    If Dolophine is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Dolophine with the following: alcohol and other CNS depressants, antiarrhythmics, antidepressants called selective serotonin reuptake inhibitors, antiretroviral medications used to treat HIV infection, azole antifungals, buprenorphine, butorphanol, carbamazepine, desipramine, erythromycin and other antibiotics in this class, monoamine oxidase inhibitors, nalbuphine, naloxone, naltrexone, pentazocine, phenobarbital, phenytoin, rifampin, or St. John's wort.

  • What are the possible side effects of Dolophine?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: lightheadedness, dizziness, drowsiness, constipation, nausea, vomiting, sweating, weakness, headache, itching, dry mouth

  • Can I receive Dolophine if I am pregnant or breastfeeding?

    The effects of Dolophine during pregnancy are unknown. Dolophine is secreted into breast milk and may harm your baby. You should choose to use Dolophine or breastfeed, but not both. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of Dolophine?

    If you miss a dose of Dolophine, take the missed dose as soon as possible. However, if it is almost time for your next dose, skip the one you missed and go back to your regular dosing schedule. Do not take two doses at once. If you are unsure, ask your doctor or pharmacist for advice.

  • How should I store Dolophine?

    Store at room temperature. Keep Dolophine away from children and in a secure place to protect from theft. Dispose of any unused Dolophine remaining from a prescription as soon as they are no longer needed. Unused tablets should be flushed down the toilet.

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