Doribax

Generic Name: Doripenem

  • What is Doribax?

    Doribax (doripenem for injection) is an antibacterial agent used to treat complicated intra-abdominal infections and complicated urinary tract infections, including pyelonephritis (infections of the kidney and the bladder).

  • What is the most important information I should know about Doribax?

    Allergic reactions, including serious reactions, can occur and require immediate treatment.

    Pseudomembranous colitis (an infection of the colon resulting in diarrhea) has been reported with nearly all antibacterial agents, including Doribax, and may range in severity from mild to life-threatening. Therefore, it is important to tell your doctor if you experience diarrhea during or after treatment with antibacterial agents such as Doribax.

    Antibacterial drugs, including Doribax, are used to treat bacterial infections only. They do not treat viral infections.

  • Who should not take Doribax?

    Do not use Doribax if you are allergic to doripenem or to any drugs in the carbapenem or beta-lactam class.

  • What should I tell my doctor before I take the first dose of Doribax?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Doribax. Also, talk to your doctor about your complete medical history, especially if you have kidney problems.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: The recommended dosage is 500 mg every 8 hours by intravenous (IV) infusion over 1 hour for 5-14 days. Some patients may require a lower dose. The duration of therapy with Doribax is determined by the kind of infection, organism causing the disease, and kidney and liver function.

  • How should I take Doribax?

    Doribax is administered intravenously by a healthcare professional in a hospital setting.

  • What should I avoid while taking Doribax?

    Do not use Doribax unless you have a proven bacterial infection.

  • What are possible food and drug interactions associated with Doribax?

    If Doribax is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Doribax with probenecid or valproic acid.

  • What are the possible side effects of Doribax?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: allergic reactions, severe diarrhea, headache, phlebitis (swelling at the injection site), nausea, rash, itching, oral candidiasis

    Signs of severe allergic reactions may include hives, difficulty breathing, and swelling of the throat. If any of these events occur, seek immediate medical attention.

  • Can I receive Doribax if I am pregnant or breastfeeding?

    The effects of Doribax during pregnancy and breastfeeding are unknown. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of Doribax?

    Ask your doctor for advice.

  • How should I store Doribax?

    Doribax will be stored by your healthcare provider.

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I'm Shereen A. Gharbia, PharmD. Welcome to PDR Health!

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