Generic Name: Famotidine

  • What is Duexis?

    Duexis is a medicine that contains ibuprofen (a nonsteroidal anti-inflammatory drug [NSAID]) and famotidine (a medicine that helps to reduce the acid in your stomach). Duexis is used to treat signs and symptoms of rheumatoid arthritis and osteoarthritis. Duexis also decreases the risk of developing ulcers of the stomach and upper intestines in people who are taking ibuprofen for rheumatoid arthritis and osteoarthritis.

  • What is the most important information I should know about Duexis?

    Duexis can cause serious problems (such as heart attack or stroke). Your risk can increase when this medication is used for long periods of time and in people who have heart disease. Tell your doctor if you experience chest pain, shortness of breath, weakness, or slurred speech. Also, Duexis can cause heart failure which can lead to weight gain or edema (swelling).

    Duexis can cause discomfort, ulcers, or bleeding in your stomach or intestines. Your risk can increase with long-term use, smoking, drinking alcohol, older age, or with certain medications. Tell your doctor immediately if you experience abdominal pain or if you have bloody vomit or stools.

    Long-term use of Duexis can cause kidney injury. Your risk can increase if you have kidney impairment; heart failure; liver problems; are taking certain medications, including diuretics (water pills) (such as furosemide) or blood/heart medications known as angiotensin-converting enzyme (ACE) inhibitors (such as lisinopril); or are elderly. Also, Duexis can cause liver injury. Tell your doctor if you experience nausea, tiredness, weakness, itchiness, yellowing of your skin or whites of your eyes, right upper abdominal tenderness, or "flu-like" symptoms.

    Duexis can cause allergic reactions resembling anaphylaxis (a serious and rapid allergic reaction that may result in death if not immediately treated). Stop taking Duexis and tell your doctor immediately if you experience difficulty breathing or swelling of your face, mouth, or throat.

    Tell your doctor immediately if you experience serious skin reactions which can be characterized by a severe rash, fever, or itchiness.

  • Who should not take Duexis?

    Do not take Duexis if you are allergic to it, any of its ingredients, or if you experienced asthma, difficulty breathing, rash, or allergic-type reactions after taking aspirin or other NSAIDs.

    Do not take Duexis right before or after a heart surgery called coronary artery bypass graft (CABG) or if you are in the late stages of your pregnancy.

  • What should I tell my doctor before I take the first dose of Duexis?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Duexis. Also, talk to your doctor about your complete medical history, especially if you have heart disease, stomach or intestinal problems, bleeding problems, liver or kidney problems, high blood pressure, asthma, are pregnant, plan to become pregnant, or are breastfeeding.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: The recommended dose is 1 tablet three times a day.

  • How should I take Duexis?

    Take Duexis exactly as prescribed by your doctor. Do not stop Duexis without first talking to your doctor.

    Swallow Duexis tablets whole. Do not cut, chew, divide, or crush the tablets.

  • What should I avoid while taking Duexis?

    Do not take aspirin or other NSAIDs in combination with Duexis.

  • What are possible food and drug interactions associated with Duexis?

    If Duexis is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Duexis with the following: ACE inhibitors, antidepressant medications (such as fluoxetine or paroxetine), aspirin, blood thinners (such as warfarin), cholestyramine, diuretics, lithium, or methotrexate.

  • What are the possible side effects of Duexis?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: constipation, diarrhea, headache, high blood pressure, nausea, stomach pain, upper respiratory tract infection

  • Can I receive Duexis if I am pregnant or breastfeeding?

    Do not take Duexis if you are in the late stage of your pregnancy. Duexis can be found in your breast milk if you take it during breastfeeding. Do not take Duexis while you are breastfeeding. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of Duexis?

    If you miss a dose of Duexis, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

  • How should I store Duexis?

    Store in the original container at room temperature. Keep it dry.