Generic Name: Selegiline hydrochloride

  • What is Eldepryl?

    Eldepryl is prescribed along with levodopa/carbidopa for people with Parkinson's disease. It is used as an add-on treatment when levodopa/carbidopa alone seems to be less effective. Eldepryl has no effect when taken by itself; it only works in combination with levodopa.
  • What is the most important information I should know about Eldepryl?

    Eldepryl belongs to a class of drugs known as MAO inhibitors. These drugs can interact with certain foods—including aged cheeses and meats, pickled herring, beer, and wine—to cause a life-threatening surge in blood pressure. At the dose recommended for Eldepryl, this interaction is not a problem. But for safety's sake, you may want to watch your diet; and you should never take more Eldepryl than the doctor prescribed (usually 10 mg daily). Rare hypertensive reactions with selegiline at recommended doses associated with dietary influences have been reported.

    Patients should be advised of the possible need to reduce levodopa dosage after the initiation of Eldepryl therapy.

    If you or your family patient experiences severe headache or other atypical or unusual symptoms not previously experienced, contact your doctor immediately.

    Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Eldepryl; this drug may cause dizziness or lightheadedness. Using Eldepryl with certain other medications or with alcohol may increase these side effects. .

    Eldepryl may cause dizziness, lightheadedness, or fainting. Alcohol, hot weather, exercise, and fever can increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Also, sit or lie down at the first sign of dizziness, lightheadedness, or weakness.

    Do not become overheated in hot weather or during exercise or other activities; heatstroke may occur.

    Before you begin taking any new prescription or over-the-counter medicine, check with your doctor or pharmacist. This includes medicines that contain pseudoephedrine, phenylpropanolamine, or dextromethorphan.

    Follow all of these precautions for at least 4 weeks after taking the last dose of Eldepryl.

  • Who should not take Eldepryl?

    Do not take Eldepryl if you are sensitive to or have ever had an allergic reaction to it. Do not take narcotic painkillers while you are taking Eldepryl. This may sometimes extend to other opioids as well.
  • What should I tell my doctor before I take the first dose of Eldepryl?

    Tell your doctor about all prescription, over-the-counter, and herbal medication you are taking before beginning treatment with this drug. Also, talk to your doctor about your complete medical history especially if you have a history of mental disorders (psychosis), tardive dyskinesia (twitching of the face and tongue, involuntary movements of the arms and legs), or ulcers.
  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: The recommended dose of Eldepryl is 10 milligrams per day divided into 2 smaller doses of 5 milligrams each, usually taken at breakfast and lunch. After 2 to 3 days of selegiline treatment, an attempt may be made to reduce the dose of levodopa/carbidopa.

  • How should I take Eldepryl?

    Take Eldepryl with food, at breakfast and lunch.

    Most people who take Eldepryl can eat a normal diet. However, if your dosage is more than 10 mg/day, serious increases in blood pressure may occur when you eat or drink some foods and drinks. Foods or drinks that may cause a reaction include aged cheeses, sour cream, red wines, beer, bologna, pepperoni, salami, summer sausage, pickled herring, liver, meat prepared with tenderizers, canned figs, raisins, bananas, avocados, soy sauce, fava beans, or yeast extracts.

    Continue to use Eldepryl even if you feel well. Do not miss any doses.

  • What should I avoid while taking Eldepryl?

    Never take Eldepryl at a higher dosage than prescribed; doing so could put you at risk for a dangerous rise in blood pressure. If you develop a severe headache or any other unusual symptoms, contact your doctor immediately.

    You may suffer a severe reaction if you combine Eldepryl with tricyclic antidepressants such as amitriptyline and imipramine, or with antidepressants that affect serotonin levels, such as fluoxetine and paroxetine. Wait at least 14 days after taking Eldepryl before beginning therapy with any of these drugs. If you have been taking antidepressants such as fluoxetine and paroxetine, you should wait at least 5 weeks before taking Eldepryl. This much time is needed to clear the antidepressant completely from your system.

    Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Eldepryl; this drug may cause dizziness or lightheadedness.

    Do not become overheated in hot weather or during exercise or other activities; heatstroke may occur.

    Avoid standing or sitting up too quickly, especially when you first begin treatment with Eldepryl. Also, sit or lie down at the first sign of dizziness, lightheadedness, or weakness.

  • What are possible food and drug interactions associated with Eldepryl?

    If Eldepryl is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Eldepryl with the following: antidepressant medications such as paroxetine, fluoxetine, and sertraline; antidepressant medications classified as tricyclics, such as amitriptyline and imipramine; antidiabetic agents such as repaglinide; anorexiants such as phentermine; bupropion; carbamazepine; cyclobenzaprine; dextromethorphan; insulin; narcotic painkillers such as meperidine, oxycodone, and codeine; sulfonylureas such as glyburide; sumatriptan; and sympathomimetics such as ephedrine and methylphenidate.
  • What are the possible side effects of Eldepryl?

    Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug. Eldepryl may worsen side effects caused by your usual dosage of levodopa.

    Side effects may include: abdominal pain, anxiety, changes in heart rate, confusion, dizziness, dry mouth, fainting, hallucinations, headache, lightheadedness, nausea, unusual body movements or difficulty moving, vomiting

  • Can I receive Eldepryl if I am pregnant or breastfeeding?

    The effects of Eldepryl during pregnancy and breastfeeding have not been adequately studied. If you are pregnant, plan to become pregnant, or breastfeeding, tell your doctor immediately.
  • What should I do if I miss a dose of Eldepryl?

    If you miss a dose of Eldepryl, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
  • How should I store Eldepryl?

    Store Eldepryl at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Eldepryl out of the reach of children.