What is Emend for Injection?Emend for Injection is a medication used in combination with other agents for the prevention of nausea and vomiting associated with initial and repeat courses of cancer chemotherapy.
What is the most important information I should know about Emend for Injection?In patients on chronic warfarin therapy, coadministration of Emend will increase clotting time. Your clotting time should be closely monitored during the 2-week period following Emend therapy, especially at 7 to 10 days after you start Emend therapy. The efficacy of hormonal contraceptives during, and 28 days after the last dose of Emend, may be reduced. Use an alternative or back-up method of contraception during treatment with Emend and for 1 month after you last dose of Emend.
Who should not take Emend for Injection?Do not take Emend if you have an allergy to Emend, aprepitant, polysorbate 80, or any of its components. Do not use Emend if you are taking astemizole, cisapride, pimozide, or terfenadine.
What should I tell my doctor before I take the first dose of Emend for Injection?Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Emend. Also, tell your doctor about your complete medical history, especially if you have liver problems, are taking any of the medications listed above, or if you are pregnant or plan to become pregnant.
What is the usual dosage?The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.
Adults: Emend for Injection (115 milligrams [mg]) may be substituted for Emend (125 mg) 30 minutes prior to chemotherapy, on Day 1 as an infusion administered over 15 minutes.
How should I take Emend for Injection?Your doctor will administer your dose 30 minutes before chemotherapy. It should only be given on Day 1 and is usually followed by Emend capsules taken by mouth on Days 2 and 3 of a 3-day regimen with each chemotherapy cycle. Emend for Injection may be given with or without food. Emend for Injection should not be given to you for long-term use.
What should I avoid while taking Emend for Injection?Avoid taking astemizole, cisapride, pimozide, or terfenadine. Women who use birth control medicines during treatment with Emend and for up to 1 month after using Emend should also use a back-up method of contraception to avoid pregnancy.
What are possible food and drug interactions associated with Emend for Injection?If Emend for Injection is used with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Emend for Injection with the following: astemizole, cisapride, diltiazem, pimozide, terfenadine, tolbutamide, warfarin.
What are the possible side effects of Emend for Injection?Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.
Side effects may include: constipation, diarrhea, dizziness, fever, hair loss, headache, heart burn, hiccups, infusion site pain, infusion site redness, loss of appetite, loss of neutrophils (type of white blood cells), muscle weakness/fatigue, nausea, ringing in the ears, sleeplessness, stomach pain, tiredness
Can I receive Emend for Injection if I am pregnant or breastfeeding?The effects of Emend for Injection during pregnancy and breastfeeding are unknown. Talk to your doctor about any potential harm to the baby if you are pregnant, plan to become pregnant, or are breastfeeding.
What should I do if I miss a dose of Emend for Injection?Ask your doctor about a missed dose before receiving chemotherapy. Emend for Injection should only be given on Day 1 of a 3-day Emend regimen.
How should I store Emend for Injection?Your doctor will store Emend for you.