Generic Name: Darifenacin

  • What is Enablex?

    Enablex is a prescription medicine used for the treatment of overactive bladder (OAB) in adults. Symptoms of OAB are having a strong need to go to the bathroom right away (urgency), leaking or wetting accidents (urinary incontinence), having to go to the bathroom too often (urinary frequency). This medication gives OAB symptom relief by targeting specific receptors on the bladder that cause involuntary muscle spasms. Enablex helps control the bladder muscle and helps restore control of urination.
  • What is the most important information I should know about Enablex?

    Do not drive or perform other possibly unsafe tasks until you know how you react to Enablex; this drug may cause dizziness or blurred vision. These effects may become worse if you take Enablex with alcohol or certain medicines.

    Heat exhaustion or heatstroke due to decreased sweating can occur while you are taking Enablex; you may become overheated in a warm environment or during increased physical activity. Seek immediate medical attention if you experience sudden or severe tiredness, weakness, anxiety, dizziness, or fainting.

    Enablex may cause urinary retention (difficulty urinating), gastric retention (delayed emptying of the stomach), and narrow angle glaucoma.

  • Who should not take Enablex?

    Do not take Enablex if you are allergic to any of its ingredients.

    Also, do not take this drug if you are not able to empty your bladder (urinary retention), have delayed or slow emptying of your stomach (gastric retention), or if you have an eye problem called uncontrolled narrow-angle glaucoma.

  • What should I tell my doctor before I take the first dose of Enablex?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Enablex. Also, talk to your doctor about your complete medical history, especially if you have any stomach or intestinal problems, or problems with constipation; have trouble emptying your bladder or you have a weak urine stream; have myasthenia gravis (muscle problems); have an eye problem called narrow-angle glaucoma; have liver problems; or if you are pregnant or plan to become pregnant.
  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: The recommended starting dose of Enablex is 7.5 milligrams (mg) once per day. Based on individual response, the dose may increase to 15mg taken once daily; this may occur as early as 2 weeks after starting therapy.

    Special populations: Patients with moderate liver impairment or those who are taking specific drugs should not exceed a daily Enablex dose of 7.5mg. Enablex is not recommended for use in patients with severe liver impairment.

    The safety and effectiveness of Enablex in pediatric patients have not been established.

  • How should I take Enablex?

    Enablex should be taken once a day with liquid, with or without food. This drug should be swallowed whole and should not be crushed, split, or chewed.
  • What should I avoid while taking Enablex?

    Avoid potentially hazardous activities (eg, driving) when beginning treatment with Enablex. The drug may cause blurred vision.

    Do not become overheated in hot weather or during activity; heatstroke may occur.

    Avoid the consumption of alcohol while you are on Enablex.

  • What are possible food and drug interactions associated with Enablex?

    If Enablex is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Enablex with the following: anticholinergic drugs, antifungal medicines, clarithromycin, digoxin, flecainide, itraconazole, ketoconazole, midazolam, nefazadone, nelfinavir, ritonavir, scopolamine, thioridazine, and tricyclic antidepressants such as amitriptyline and imipramine.
  • What are the possible side effects of Enablex?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: blurred vision, constipation, dry mouth, overheated feeling, diarrhea, dizziness, dry eyes, flu-like symptoms, headache, nausea, stomach pain, stomach upset, weakness, back pain, bloody or cloudy urine, inability to urinate despite an urge to do so

  • Can I receive Enablex if I am pregnant or breastfeeding?

    The effects of Enablex during pregnancy and breastfeeding are unknown. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
  • What should I do if I miss a dose of Enablex?

    If you miss a dose of Enablex, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
  • How should I store Enablex?

    Store Enablex at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Enablex out of the reach of children.