Endometrin

Generic Name: Progesterone

  • What is Endometrin?

    Endometrin is a vaginal insert that contains the hormone progesterone. Endometrin is used in infertile women who need extra progesterone for pregnancy support while undergoing treatment in an assisted reproductive technology (ART) program. Progesterone is one of the hormones essential to help you to become and stay pregnant.

  • What is the most important information I should know about Endometrin?

    It is important not to use any other vaginal products while using Endometrin. Report any irregular vaginal bleeding. Your doctor will need to monitor you if you have had a history of depression.

  • Who should not take Endometrin?

    Do not use Endometrin if you are allergic to any of its ingredients, have unusual vaginal bleeding that has not been evaluated by a doctor, have had a known or missed abortion or ectopic pregnancy, or currently have or have had liver problems or blood clots in the legs, lungs, eyes, or elsewhere in your body.

  • What should I tell my doctor before I take the first dose of Endometrin?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Endometrin. Also, talk to your doctor about your complete medical history, especially if you have a history of depression.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    The dose of Endometrin is 100 milligrams (mg) administered vaginally two or three times daily starting the day after retrieving your eggs from the ovaries and continuing for up to 10 weeks.

  • How should I take Endometrin?

    Use Endometrin exactly as prescribed. The usual dose of Endometrin is one insert placed in your vagina two to three times a day for up to a total of 10 weeks, unless your healthcare provider advises otherwise. Place an Endometrin insert in your vagina with the disposable applicator provided.

    To use this medication, unwrap the applicator then put one insert in the space provided at the end of the applicator. The insert should fit snugly and not fall out. Place applicator with the insert into the vagina while you are standing, sitting, or when lying on your back with your knees bent. Gently place the thin end of the applicator well into the vagina. Push the plunger to release the insert. Lastly, remove the applicator and dispose of it.

  • What should I avoid while taking Endometrin?

    Do not use any other vaginal medications while on this medication.

  • What are possible food and drug interactions associated with Endometrin?

    If Endometrin is used with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Endometrin with carbamazepine, rifampin, or vaginal products such as antifungals.

  • What are the possible side effects of Endometrin?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: pelvic pain after surgery, abdominal pain, nausea, swollen ovaries (ovarian hyperstimulation syndrome), abdominal bloating, headache, urinary infections, uterine cramping, constipation, vomiting, tiredness, vaginal bleeding, breast tenderness, mood swings, and irritability

    Warning signs of serious side effects (stop taking Endometrin and call your doctor): Unusual vaginal bleeding, persistent pain in the lower leg (calf), sudden shortness of breath, coughing up blood, sudden blindness (partial or complete), severe chest pain, severe headaches, vomiting, dizziness, or fainting, weakness in an arm or leg, or trouble speaking, yellowing of the skin/whites of eyes

    Patients with a history of depression need to be closely observed. Consider discontinuation if symptoms worsen.

  • Can I receive Endometrin if I am pregnant or breastfeeding?

    This medication should be used early in the pregnancy if indicated by your doctor. The effect of Endometrin in breastfeeding has not been established.

  • What should I do if I miss a dose of Endometrin?

    If you forget a dose of Endometrin, take the dose as soon as you remember, but do not use more than your daily dose.

  • How should I store Endometrin?

    Store at room temperature. Do not use Endometrin after the expiration date that is printed on the carton.

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I'm Kristen Dore, PharmD. Welcome to PDR Health!

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