Generic Name: Estropipate

  • What is Estropipate?

    Estropipate is a form of estrogen, the female sex hormone necessary for many bodily processes. Estropipate tablets are used to treat symptoms of menopause, deficiency in ovary function (including underdevelopment of female sexual characteristics and some types of infertility), and to prevent osteoporosis. Estropipate tablets and vaginal cream are used for degeneration of the vagina associated with menopause.

  • What is the most important information I should know about Estropipate?

    Because estrogens have been linked with increased risk of endometrial cancer (cancer in the lining of the uterus) in post-menopausal women, it is essential to have regular check-ups and to report any unusual vaginal bleeding to your doctor immediately.

    Long-term treatment with estrogens may increase the risk of heart attack, stroke, invasive breast cancer, and blood clots in lungs and legs. Because of these risks, contact your doctor or healthcare provider to discuss your individual risks and benefits before taking an estrogen long-term. You should also talk to your doctor or healthcare provider every 3-6 months about whether you should continue this treatment.

    Women who take estrogen after menopause are more likely to develop gallbladder disease and are also at risk for developing dementia and vision abnormalities.

  • Who should not take Estropipate?

    Do not start taking estropipate if you have unusual vaginal bleeding, have a history of certain cancers, had a stroke or heart attack in the past year, a history of blood clots, currently have or have had liver problems, are allergic to estropipate or any of its ingredients, or think you may be pregnant.

  • What should I tell my doctor before I take the first dose of Estropipate?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with estropipate. Also, talk to your doctor about your complete medical history, especially if you have a history of asthma (wheezing); epilepsy (seizures); migraine; endometriosis; problems with your heart, liver, thyroid, or kidneys; have high calcium levels in your blood; if you are going to have surgery or will be on bedrest; or are breastfeeding.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Hot Flushes and Night Sweats

    Adults: The usual dose ranges from one 0.625-milligram (mg) tablet to two 2.5-mg tablets per day. Tablets should be taken in cycles, according to your doctor's instructions.

    Vaginal Inflammation and Dryness


    Tablets: The usual dose ranges from one 0.625-mg tablet to two 2.5-mg tablets per day. Tablets should be taken in cycles, according to your doctor's instructions.

    Vaginal Cream: The usual dose is 2-4 grams (g) daily inserted in the vagina. Cream should be used in cycles, and only for limited periods of time.

    Estrogen Hormone Deficiency

    Adults: The usual dose ranges from one 1.25-mg tablet to three 2.5-mg tablets per day, taken for 3 weeks, followed by a rest period of 8-10 days.

    Ovarian Failure

    Adults: The usual dose ranges from one 1.25-mg tablet to three 2.5-mg tablets per day for 3 weeks, followed by a rest period of 8-10 days. Your doctor may increase or decrease your dosage according to your response.

    Prevention of Osteoporosis

    Adults: The usual dose is one 0.625-mg tablet per day for 25 days of a 31-day monthly cycle.

  • How should I take Estropipate?

    Tablets: Take each dose with a full glass of water. Take estropipate with food or milk to lessen stomach upset. Try to take each dose at the same time each day. You may be taking it every day, or you may be taking it every day for 3 weeks with 1 week off each month to mimic your body's natural cycle. Follow the directions on your prescription label.

    Vaginal Cream: Remove cap from tube. Make sure plunger of applicator is all the way into the barrel. Screw nozzle end of applicator onto the tube. Squeeze nozzle end of applicator onto the tube. Squeeze tube to force sufficient cream into applicator so that the number on plunger indicating prescribed dose is level with top of barrel. Unscrew applicator from tube and replace cap on tube. To deliver medication, insert end of applicator into vagina and push plunger all the way down.

    Between uses, pull plunger out of barrel and wash applicator in warm, soapy water. Do not put applicator in hot or boiling water.

  • What should I avoid while taking Estropipate?

    There are no restrictions on food, beverages, or activity while taking estropipate unless your doctor directs otherwise.

  • What are possible food and drug interactions associated with Estropipate?

    If estropipate is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining estropipate with any of the following: barbiturates (such as phenobarbital), blood thinners, clarithromycin, epilepsy drugs, erythromycin, grapefruit juice, itraconazole, ketoconazole, ritonavir, rifampin, St. John's Wort, and tricyclic antidepressants.

  • What are the possible side effects of Estropipate?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: abdominal cramps, bloating, breakthrough bleeding, breast enlargement, breast tenderness and secretions, change in amount of cervical secretion, changes in sex drive, changes in vaginal bleeding patterns, chorea (irregular, rapid, jerky movements, usually affecting the face and limbs), depression, dizziness, enlargement of benign tumors (fibroids), excessive hairiness, fluid retention, hair loss, headache, inability to use contact lenses, menstrual changes, migraine, nausea, reduced ability to tolerate carbohydrates, spotting, spotty darkening of the skin, especially around the face, skin eruptions (especially on the legs and arms) with bleeding, skin irritation, skin redness and scaling, vaginal yeast infection, vision problems, vomiting, weight gain or loss, yellow eyes and skin

  • Can I receive Estropipate if I am pregnant or breastfeeding?

    Estrogens should not be used during pregnancy. If you are pregnant or plan to become pregnant, notify your doctor immediately. These drugs may appear in breast milk and could affect a nursing infant. If estropipate is essential to your health, your doctor may advise you to discontinue breastfeeding until your treatment is finished.

  • What should I do if I miss a dose of Estropipate?

    If you do miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take only your next regularly scheduled dose. Do not take two doses at once.

  • How should I store Estropipate?

    Store estropipate at room temperature.

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