Evamist

Generic Name: Estradiol

  • What is Evamist?

    Evamist is a medicine that contains an estrogen hormone (estradiol). It is used after menopause to reduce moderate to severe hot flashes.

  • What is the most important information I should know about Evamist?

    Estrogens increase the chance of getting cancer of the uterus. Report any unusual vaginal bleeding right away while you are using Evamist. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Your healthcare provider should check any unusual vaginal bleeding to find out the cause.

    Do not use estrogens with or without progestins to prevent heart disease, heart attacks, strokes, or dementia. Using estrogens, with or without progestins, may increase your chance of getting heart attack, stroke, breast cancer, or blood clots. Using estrogen, with or without progestins, may increase your chance of getting dementia, based on a study of women ≥65 years. You and your healthcare provider should talk regularly about whether you still need treatment with Evamist.

  • Who should not take Evamist?

    Do not use Evamist if you have unusual vaginal bleeding, a history cancer (including cancer of the breast or the uterus), had a stroke or heart attack in the past year, a history of blood clots or liver problems, are allergic to Evamist or any of its ingredients, or if you think you may be pregnant.

  • What should I tell my doctor before I take the first dose of Evamist?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Evamist. Also, talk to your doctor about your complete medical history, especially about any preexisting conditions such as asthma, seizures, migraine, endometriosis, lupus, problems with the heart, liver, kidneys, or thyroid, elevated calcium levels in blood, or if you are scheduled for any surgery or will require bed rest. Tell your healthcare provider if you are breastfeeding.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: The recommended initial dosage is 1 spray per day.

  • How should I take Evamist?

    Evamist is available in a spray applicator that delivers a measured amount of estradiol to the skin with each spray.

    Before using the applicator for the first time, it must be primed. With the cover on, and the applicator upright, fully depress the applicator three times with your thumb or index finger. This is called priming. After priming, the applicator is ready to use. The applicator should be primed only once when you first start using a new applicator. Do not prime the applicator before each day's dose.

    Apply Evamist at the same time each day.

    Apply your daily dose of Evamist to clean, dry, unbroken skin on the inside of the forearm between the elbow and the wrist. Do not apply Evamist to other areas of the skin. To apply the dose, remove the plastic cover, hold the applicator upright and rest the plastic cone flat against the skin. You may need to change the position of your arm or the position of the cone on your arm so that the cone is flat against your skin and there are no gaps between the cone and your skin. Depress the pump fully once.

    If your healthcare provider tells you to increase the dose to 2 or 3 sprays, you should move the cone before applying the second or third spray to an area of the skin next to, but not touching, the area of the previous spray.

    Always place the protective cover back on the cone of the applicator.

    Do not massage or rub Evamist into the skin. Simply allow the spray to dry for at least 2 minutes before dressing, and at least 30 minutes before washing.

    Evamist contains alcohol, and alcohol-based liquids are flammable. Avoid fire, flame or smoking when using Evamist until the spray has dried. Do not apply Evamist while standing near a flame.

    Never apply Evamist directly to the breast or in or around the vagina.

  • What should I avoid while taking Evamist?

    Do not allow others to come in contact with the area of skin where you applied Evamist for at least 30 minutes.

    Do not apply Evamist to your face, breast, or irritated skin.

    Do not massage Evamist into the skin or apply in or around the vagina.

    Avoid fire, flame, or smoking as Evamist contains alcohol.

  • What are possible food and drug interactions associated with Evamist?

    If Evamist is used with certain other drugs, the effect of either medication could be increased, decreased, or altered. It is especially important to check with your doctor before combining Evamist with other medications.

  • What are the possible side effects of Evamist?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: breast lumps, unusual vaginal bleeding, dizziness, chest pain, shortness of breath, headache, breast pain, hair loss, irregular vaginal bleeding, high blood pressure, high blood sugar, vaginal yeast infection, fluid retention, liver problems, enlargement of benign tumors of the uterus, gallbladder disease

  • Can I receive Evamist if I am pregnant or breastfeeding?

    Evamist is to be avoided during pregnancy and in nursing mothers.

  • What should I do if I miss a dose of Evamist?

    If you miss a dose, do not double the dose on the next day to catch up. If your next dose is less than 12 hours away, it is best just to wait and apply your normal dose the next day. If it is more than 12 hours until the next dose, apply the dose you missed and resume your normal dosing the next day.

  • How should I store Evamist?

    Store in a clean, dry place at room temperature.

    Do not use this applicator for more than 75 sprays even though the bottle may not be completely empty.

Meet the Pharmacists

I'm Beth Isaac, PharmD. Welcome to PDR Health!

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