Generic Name: Fosinopril

  • What is this medication and its most common uses?

    Fosinopril/hydrochlorothiazide (HCTZ) is a medicine used to treat high blood pressure. It contains two medicines that work in two different ways to reduce your blood pressure: fosinopril and HCTZ.

  • What should I know when beginning and continuing on this medication?

    How does this medication work?

    Fosinopril works by blocking a chemical in your body that causes blood vessels to narrow. By blocking this chemical, fosinopril relaxes and widens your blood vessels, allowing your blood to flow through with less resistance. HCTZ is a water pill and works by eliminating extra fluid and sodium (salt) from your body. Together, they help lower your blood pressure.

    What are the beneficial effects of this medication and when should I begin to have results?

    What: By lowering your blood pressure, fosinopril/HCTZ may lower your risk of a stroke or a heart attack.

    When: Fosinopril/HCTZ may start lowering your blood pressure within a few hours after taking it. Though you may not feel an improvement or change in the way you feel, it is very important to keep taking your medicine as prescribed to keep your condition under control.

    How do I know it is working?

    Check your blood pressure regularly. Your healthcare provider will also check your blood pressure at every visit. Following an appropriate diet and exercise plan will also affect your blood pressure results.

  • What are the possible side effects of this medication?

    The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

    Fosinopril/HCTZ can harm your unborn baby. Talk to your healthcare provider about other ways to lower your blood pressure if you plan to become pregnant. Tell your healthcare provider right away if you become pregnant while taking fosinopril/HCTZ.

    More common side effects may include: Cough, fatigue, dizziness.

    Less common side effects may include:

    Serious allergic reaction with symptoms such as extreme swelling of your face, lips, tongue, throat, or gut (causing severe abdominal [stomach area] pain). You may have an increased risk of experiencing these symptoms if you are African American.

    Low blood pressure with symptoms such as lightheadedness, especially during the first few days of taking fosinopril/HCTZ. Dehydration, excessive sweating, diarrhea, or vomiting can lead to an excessive fall in your blood pressure, which can cause lightheadedness and possible fainting.

    Kidney problems with symptoms such as swelling in your feet, ankles, or hands; or unexplained weight gain.

    Low blood neutrophil (type of blood cells that fight infections) levels with symptoms of an infection (such as sore throat or fever).

    Changes in electrolytes (chemicals that are important for the cells in your body to function, such as sodium and potassium) with symptoms such as dry mouth, thirst, weakness, tiredness, drowsiness, restlessness, muscle pains or cramps, muscle tiredness, dizziness or fainting, low or no urine output, fast heartbeat, or nausea and vomiting.

  • Who should not take this medication?

    Do not take fosinopril/HCTZ if you are allergic to it, any of its ingredients, or other sulfonamide medications (such as sulfamethoxazole).

    Do not take fosinopril/HCTZ if you are unable to produce urine.

  • What should I tell my healthcare provider before I take the first dose of this medication?

    Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with fosinopril/HCTZ. Also, talk to your healthcare provider about your complete medical history, especially if you have diabetes; asthma; a disease that affects your immune system (such as lupus or scleroderma); gout; high cholesterol levels; kidney, liver, or heart problems; plan to undergo surgery or receive anesthesia; or if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

    Adults: Your healthcare provider will prescribe the appropriate dose for you based on your previous blood pressure medication.

  • How should I take this medication?

    Take fosinopril/HCTZ exactly as prescribed by your healthcare provider. Do not change your dose or stop taking fosinopril/HCTZ without first talking to your healthcare provider.

    Do not take antacids and fosinopril/HCTZ at the same time. Separate dosing of antacids and fosinopril/HCTZ by 2 hours.

  • What should I avoid while taking this medication?

    Do not become pregnant while taking this medication.

    Do not become dehydrated. Drink plenty of fluids while you are taking fosinopril/HCTZ.

    Do not take potassium supplements or salt substitutes that contain potassium without first talking to your healthcare provider.

  • What are the possible food and drug interactions associated with this medication?

    If fosinopril/HCTZ is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining fosinopril/HCTZ with the following: alcohol, antacids, barbiturates (such as phenobarbital), cholestyramine, colestipol, injectable gold (sodium aurothiomalate), insulin, lithium, methenamine, muscle relaxants (such as tubocurarine), narcotic painkillers (such as hydrocodone or oxycodone), nonsteroidal anti-inflammatory drugs (NSAIDs) (such as ibuprofen or naproxen), norepinephrine, potassium supplements or salt substitutes containing potassium, or water pills (such as amiloride, spironolactone, or triamterene).

  • May I receive this medication if I am pregnant or breastfeeding?

    Do not take fosinopril/HCTZ if you are pregnant or breastfeeding. Fosinopril/HCTZ can harm your unborn baby. Fosinopril/HCTZ can be found in your breast milk if you take it while breastfeeding. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of this medication?

    If you miss a dose of fosinopril/HCTZ, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

  • How should I store this medication?

    Store at room temperature. Protect from moisture.