What is Humatrope?Humatrope is a medicine that contains human growth hormone. It is used as a replacement for natural growth hormone in adults with growth hormone deficiency (GHD). It is also used to treat children with growth failure due to GHD, Turner syndrome, idiopathic short stature, stature homeobox-containing gene (SHOX) deficiency, or being born small for gestational age (SGA). Humatrope is administered subcutaneously (just below the skin).
What is the most important information I should know about Humatrope?While you are on Humatrope, increased pressure in your brain can occur, and may include papilledema (swelling of the optic disk), visual changes, headache, nausea, and/or vomiting. Tell your doctor if you experience any of these symptoms.
If you have tumors or lesions in your brain, you should be monitored for worsening or recurrence of the tumor or lesions. In addition, Humatrope can cause a second tumor, especially in your brain, after receiving radiation to your head for the first tumor.
Humatrope can increase your blood sugar levels. Check your blood sugar levels regularly. Your doctor may need to adjust the dose of your diabetes medications.
Humatrope can cause pancreatitis (inflammation of the pancreas). Tell your doctor if you experience abdominal pain while using Humatrope.
Humatrope can also cause or worsen hypothyroidism (an underactive thyroid gland) and cause fluid retention, especially in adults.
In children, Humatrope can cause a progression of scoliosis (curving of the spine) or skeletal abnormalities in children with Turner syndrome or Prader-Willi syndrome (rare genetic disorders). It can also cause ear infections, other ear disorders, high blood pressure, stroke, or heart disorders in children with Turner syndrome.
Slip of the ball of the hip joint can occur in children who have endocrine problems and in children who have rapid growth. Tell your doctor if your child experiences limping or pain in his/her knee or hip.
Who should not take Humatrope?Do not use Humatrope if you are allergic to it, any of its ingredients, metacresol, or glycerin. Also, do not use Humatrope if you have eye problems caused by diabetes, active cancer, or if you have a serious medical condition after having an open heart or abdominal surgery, serious injuries involving many body systems, or breathing problems (such as sudden respiratory failure).
What should I tell my doctor before I take the first dose of Humatrope?Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Humatrope. Also, talk to your doctor about your complete medical history, especially if you have heart or abdominal surgery, trauma, respiratory problems, cancer or other tumors, multiple hormone deficiencies, pancreatitis, hypothyroidism, scoliosis, ear disorders or infections, or diabetes.
What is the usual dosage?The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.
Adults: Your doctor will prescribe the appropriate dose for you based on your condition or weight.
Children: Your doctor will prescribe the appropriate dose for your child, based on their weight.
How should I take Humatrope?Use Humatrope exactly as prescribed by your doctor. Let the Humatrope pen with the cartridge stand at room temperature for 10 minutes, but less than 30 minutes, before injecting to avoid discomfort.
Change the sites of injection (abdomen, thigh, buttocks, or arms) every day to avoid injection-site reactions (such as redness or pain). Remove the needle immediately after each injection; a new needle must be used for each injection. You can clean the pen with a damp cloth.
Your doctor will show you and/or your caregiver how to inject this medicine, as well as how to properly dispose syringes and needles. Please review the instructions that came with your prescription on how to properly use Humatrope.
What should I avoid while taking Humatrope?When mixing Humatrope, do not use other solutions for reconstitution unless instructed to do so by your doctor. After mixing, do not shake the solution, and do not inject the solution if it is cloudy or contains particles.
Do not use alcohol or other cleaning agents to clean the pen. Do not soak or immerse the pen in liquid. Also, do not apply oil or any other lubricant.
Do not use the pen if any part of the pen or cartridge appears broken or damaged. Also, do not remove the cartridge from the pen until the cartridge is empty or needs to be replaced.
What are possible food and drug interactions associated with Humatrope?If Humatrope is used with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Humatrope with the following: cyclosporine, diabetes medications, glucocorticoids (such as prednisone), insulin, seizure medications, or sex steroids (such as estrogen, progesterone, or testosterone).
What are the possible side effects of Humatrope?Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.
Side effects may include: allergic reactions, breast enlargement, carpal tunnel syndrome (a nerve disorder that causes numbness, tingling, or burning sensations in the thumb and fingers), ear problems, headache, high blood sugar levels, hip pain, infections, injection-site reactions, joint or muscle pain, numbness or tingling sensation in your skin, scoliosis, swelling, swollen hands or feet due to fluid retention
Can I receive Humatrope if I am pregnant or breastfeeding?The effects of Humatrope during pregnancy and breastfeeding are unknown. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
What should I do if I miss a dose of Humatrope?If you miss a dose of Humatrope, inject it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not inject two doses at once.
How should I store Humatrope?Store in the refrigerator. After mixing, use the vial within 14 days or the cartridge within 28 days. Do not freeze.