Hyzaar

Generic Name: Losartan

  • What is this medication and its most common uses?

    Hyzaar is a medicine used to treat high blood pressure and to lower the risk of stroke in people who have high blood pressure and a heart condition called left ventricular hypertrophy. Hyzaar contains two medicines that work in two different ways to reduce your blood pressure and lower your risk of stroke: losartan and hydrochlorothiazide.

  • What should I know when beginning and continuing on this medication?

    How does this medication work?

    Losartan works by blocking a chemical in your body that causes blood vessels to narrow. By blocking this chemical, losartan relaxes and widens your blood vessels, allowing your blood to flow through with less resistance. Hydrochlorothiazide is a water pill and works by eliminating extra fluid and sodium (salt) from your body.

    What are the beneficial effects of this medication and when should I begin to have results?

    What: By lowering your blood pressure, Hyzaar may lower your risk of a stroke or a heart attack.

    When: Hyzaar may start lowering your blood pressure within 1 week. Though you may not feel an improvement or change in the way you feel, it is very important to keep taking your medicine as prescribed to keep your condition under control.

    How do I know it is working?

    Check your blood pressure regularly. Your healthcare provider will also check your blood pressure at every visit. Following an appropriate diet and exercise plan will also affect your blood pressure results.

  • What are the possible side effects of this medication?

    The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

    Hyzaar can harm your unborn baby. Talk to your healthcare provider about other ways to lower your blood pressure if you plan to become pregnant. Tell your healthcare provider right away if you become pregnant while taking Hyzaar.

    More common side effects may include: upper respiratory infection, dizziness.

    Less common side effects may include:

    Low blood pressure with symptoms such as lightheadedness, especially during the first few days of taking Hyzaar. Dehydration, excessive sweating, diarrhea, or vomiting can lead to an excessive fall in your blood pressure, which can cause lightheadedness and possible fainting.

    Allergic reactions with symptoms such as swelling of your face, lips, throat, or tongue.

    Temporary nearsightedness (trouble seeing objects farther away) or glaucoma (high pressure in the eye) with symptoms such as changes in your vision or eye pain that may occur within hours to weeks of starting Hyzaar.

    Changes in electrolytes (chemicals that are important for the cells in your body to function, such as sodium and potassium) with symptoms such as dry mouth, thirst, weakness, tiredness, drowsiness, restlessness, muscle pains or cramps, muscle tiredness, dizziness or fainting, low or no urine output, fast heartbeat, or nausea and vomiting.

    Kidney problems with symptoms such as swelling in your feet, ankles, or hands; or unexplained weight gain.

  • Who should not take this medication?

    Do not take Hyzaar if you are allergic to it, any of its ingredients, or other sulfonamide medications (such as sulfamethoxazole).

    Do not take Hyzaar if you are unable to produce urine.

    If you are diabetic, do not take Hyzaar in combination with aliskiren.

  • What should I tell my healthcare provider before I take the first dose of this medication?

    Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Hyzaar. Also, talk to your healthcare provider about your complete medical history, especially if you have diabetes; asthma; lupus (a disease that affects the immune system); gout; high cholesterol levels; kidney, liver, or heart problems; or if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

    Adults: The usual dose is 50/12.5 (50 milligrams [mg] of losartan and 12.5 mg of hydrochlorothiazide) once a day. Your healthcare provider may increase your dose as needed until the desired effect is achieved.

  • How should I take this medication?

    Take Hyzaar exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Hyzaar without first talking to your healthcare provider.

    Take Hyzaar with or without food.

  • What should I avoid while taking this medication?

    Do not become pregnant while taking this medication.

    Do not become dehydrated. Drink plenty of fluids while you are taking Hyzaar.

    Do not take potassium supplements or salt substitutes that contain potassium without first talking to your healthcare provider.

  • What are the possible food and drug interactions associated with this medication?

    If Hyzaar is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Hyzaar with the following: alcohol, aliskiren, barbiturates (such as phenobarbital), blood pressure/heart medications known as angiotensin-converting enzyme (ACE) inhibitors (such as enalapril or lisinopril), certain water pills (such as amiloride, spironolactone, or triamterene), cholestyramine, colestipol, diabetes medicines (such as insulin), fluconazole, lithium, muscle relaxants (such as tubocurarine), narcotic painkillers (such as hydrocodone or oxycodone), nonsteroidal anti-inflammatory drugs (NSAIDs) (such as ibuprofen or naproxen), norepinephrine, potassium supplements, rifampin, salt substitutes that contain potassium, or steroids (such as prednisone).

  • May I receive this medication if I am pregnant or breastfeeding?

    Do not take Hyzaar if you are pregnant or breastfeeding. Hyzaar can harm your unborn baby. Hyzaar can be found in your breast milk if you take it while breastfeeding. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of this medication?

    If you miss a dose of Hyzaar, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

  • How should I store this medication?

    Store at room temperature. Protect from light.

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