Incivek

Generic Name: Telaprevir

  • What is Incivek?

    Incivek is a medication used in combination with peginterferon alfa and ribavirin to treat chronic (lasting a long time) hepatitis C infection in adults with stable liver problems, who have not been treated before or who have failed previous treatment.

  • What is the most important information I should know about Incivek?

    Do not take Incivek alone to treat chronic hepatitis C infection. Incivek must be used with peginterferon alfa and ribavirin to treat chronic hepatitis C infection.

    Incivek in combination with peginterferon alfa and ribavirin may cause birth defects or death of your unborn baby. You, or your sexual partner, should not become pregnant while taking these medications and for 6 months after treatment is over. You must have a negative pregnancy test before starting treatment, each month during treatment, and for 6 months after your treatment ends. You must use 2 forms of effective birth control during treatment and for 6 months after treatment is over.

    Mild skin rashes are common with Incivek combination treatment. Sometimes these skin rashes and other skin reactions can become severe and require treatment in a hospital. Tell your doctor immediately if you develop any skin changes with any of the following symptoms: rash, with or without itching; blisters or skin lesions; mouth sores or ulcers; red or inflamed eyes, such as "pink eye" (conjunctivitis); swelling of your face; and fever.

    Do not stop taking Incivek without talking with your doctor first.

  • Who should not take Incivek?

    Do not take Incivek if you are allergic to it or any of its ingredients, if you are pregnant or may become pregnant, or are a man with a sexual partner who is pregnant.

  • What should I tell my doctor before I take the first dose of Incivek?

    Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Incivek. Also, talk to your doctor about your complete medical history, especially if you have low red blood cell counts (anemia), have liver problems other than hepatitis C infection, have hepatitis B infection, have human immunodeficiency virus (HIV) infection (AIDS), history of severe and painful inflammation of the joints (gout) or high uric acid levels, have had an organ transplant, plan to have surgery, are pregnant, plan to become pregnant, or are breastfeeding.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

    Adults: The usual dose is 750 milligrams (mg), (two 375-mg tablets), 3 times a day taken 7-9 hours apart.

  • How should I take Incivek?

    Take Incivek exactly as prescribed by your doctor. Always take Incivek with food. Eat a meal or snack that contains about 20 grams of fat 30 minutes before you take each dose of Incivek.

  • What should I avoid while taking Incivek?

    You, or your sexual partner, should avoid becoming pregnant while taking this medication.

  • What are possible food and drug interactions associated with Incivek?

    If Incivek is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Incivek with the following: alfuzosin, atorvastatin, ergot containing medicines such as methylergonovine, lovastatin, pimozide, rifampin, sildenafil or tadalafil for pulmonary artery hypertension (lung problem), simvastatin, St. John's wort or products containing St. John's wort, or triazolam.

  • What are the possible side effects of Incivek?

    Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

    Side effects may include: dizziness, low red blood cell counts, shortness of breath, tiredness, weakness

  • Can I receive Incivek if I am pregnant or breastfeeding?

    Do not use Incivek if you are pregnant or breastfeeding. Incivek may cause harm or even death to the unborn baby. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of Incivek?

    If you miss a dose of Incivek within 4 hours of when you usually take it, take your dose with food as soon as possible. If you miss a dose and it is more than 4 hours after the time you usually take it, skip that dose only and take the next dose at your normal dosing schedule.

  • How should I store Incivek?

    Store at room temperature.