What is Increlex?Increlex is a manmade insulin-like growth factor-1 (IGF-1), which is the same as the IGF-1 made by your body. Increlex is used to treat children who are very short for their age because their bodies do not make enough IGF-1, a condition called primary IGF-1 deficiency.
What is the most important information I should know about Increlex?This drug should not be used instead of growth hormone and should not be given through a vein.
Always carry a source of sugar, such as candy, glucose tablets, or juice as this medication may result in decreased blood sugar levels.
Who should not take Increlex?Increlex should not be used if a child has finished growing (the bone growth plates are closed), has cancer, has other causes of growth failure, or is allergic to mecasermin or any of the ingredients in Increlex.
What should I tell my doctor before I take the first dose of Increlex?Talk to your doctor about all prescription, over-the-counter, and herbal medications your child is taking. Tell the doctor about all of your child's health conditions, including if he or she has diabetes, kidney or liver problems, a curved spine (scoliosis), or is pregnant or breastfeeding.
What is the usual dosage?The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.
Children: The recommended starting dose of Increlex is 0.04 to 0.08 milligrams (mg)/kilograms (kg) twice daily by injection. If well-tolerated for at least 1 week, the doctor may increase the dose by 0.04 mg/kg per dose, to the maximum dose of 0.12 mg/kg given twice daily.
How should I take Increlex?Inject Increlex (your doctor or nurse will teach you how) under your child's skin (upper arm, upper leg/thigh, stomach area, or buttocks). Give the injection 20 minutes before or after a meal or snack. Never inject it into a vein or muscle.
Change the injection site for each injection. Skip your child's dose of Increlex if he or she cannot eat before or after 20 minutes of the scheduled dose for any reason.
What should I avoid while taking Increlex?Do not inject your child with Increlex if he or she has not eaten. Do not use the injection if it appears cloudy or colored. Increlex should be clear and colorless.
What are possible food and drug interactions associated with Increlex?Tell your doctor about all prescription, over-the-counter, and herbal medications your child is on before beginning therapy with Increlex.
What are the possible side effects of Increlex?Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.
Side effects may include: dizziness, enlarged tonsils, fast heartbeat, hunger, irritability, low blood sugar, nausea, sweating, fatigue, trouble concentrating, worsening of scoliosis (curved spine)
What should I do if I miss a dose of Increlex?Skip the missed dose and take the next at the usual time. Do not take 2 doses at once.
How should I store Increlex?Store unopened vials in the refrigerator. You can store opened vials in the refrigerator for up to 30 days. Do not freeze Increlex. Protect from direct light.