Generic Name: Paliperidone

  • What is this medication and its most common uses?

    Invega is a medicine used to treat schizophrenia (a brain disorder that distorts the way a person thinks, acts, expresses emotions, perceives reality, and relates to others). It is also used alone or in combination with other medicines to treat schizoaffective disorder (a serious mental illness that has features of two different conditions, schizophrenia and either major depression or bipolar disorder).

  • What should I know when beginning and continuing on this medication?

    How does this medication work?

    Although it is unclear exactly how Invega works, it seems to help balance the chemicals in the brain, thereby helping to improve your symptoms.

    What are the beneficial effects of this medication and when should I begin to have results?

    What: Invega has been shown to relieve symptoms of schizophrenia and schizoaffective disorder, as measured by symptom rating scales that are commonly used by healthcare providers to evaluate the effectiveness of the medicine in people with these conditions.

    When: Everyone responds differently to treatment, so try to be patient and follow your healthcare provider's directions. It is important that you take Invega exactly as your healthcare provider has prescribed.

    How do I know it is working?

    Your healthcare provider may ask you questions from time to time to assess how well your symptoms are controlled.

  • What are the possible side effects of this medication?

    The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

    Invega is not approved to treat mental problems caused by dementia (an illness involving loss of memory and judgment, and confusion) in the elderly. It can be life-threatening when used in elderly people with mental problems caused by dementia.

    Schizophrenia (Adults)

    More common side effects may include: involuntary muscle movements, fast heart beat, restlessness.

    Schizophrenia (Adolescents)

    More common side effects may include: drowsiness, restlessness, shaking, movement disorder, anxiety, weight gain, fast heart beat.

    Schizoaffective Disorder (Adults)

    More common side effects may include: involuntary muscle movements, drowsiness, upset stomach, constipation, weight gain, common cold.

    Less common side effects of Invega may include:

    Neuroleptic malignant syndrome (NMS) (a life-threatening brain disorder) with symptoms such as high fever, excessive sweating, muscle rigidity, confusion, changes in your breathing, fast or irregular heartbeat, or changes in your blood pressure.

    Changes in the electrical activity of your heart, with symptoms such as chest pain, fast or slow heartbeat, shortness of breath, and dizziness or fainting.

    Tardive dyskinesia, defined as abnormal muscle movements, including tremor, shuffling, and uncontrolled, involuntary movements.

    High blood sugar with symptoms such as excessive thirst, an increase in urination, increased appetite, weakness, confusion, fruity smelling breath, or feeling sick to your stomach.

    Increased cholesterol (fats in your blood) and triglycerides (a type of blood fat), and weight gain.

    Increased prolactin (a hormone that can affect lactation, menstruation, and fertility) levels, with side effects including missed menstrual periods, leakage of milk from the breasts, development of breasts in men, or problems with erection.

    Sudden fall in blood pressure with symptoms such as dizziness, lightheadedness, or fainting when rising too quickly from a sitting or lying position.

    Low white blood cell counts with symptoms of an infection (such as fever, sore throat, rash, or chills).

  • Who should not take this medication?

    Do not take Invega if you are allergic to it, any of its ingredients, or to a similar medicine called risperidone.

  • What should I tell my healthcare provider before I take the first dose of this medication?

    Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Invega. Also, talk to your healthcare provider about your complete medical history, especially if you have diabetes; high cholesterol levels; high or low blood pressure; low white blood cell counts; seizures; high prolactin levels; heart or kidney problems; narrowing or blockage of your stomach or intestines; Alzheimer's disease; Parkinson's disease; thoughts about suicide; or if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What is the usual dosage?

    The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.


    Adults: The recommended dose is 6 milligrams (mg) once a day.

    Adolescents 12-17 years: The recommended starting dose is 3 mg once a day.

    Schizoaffective Disorder

    Adults: The recommended dose is 6 mg once a day.

    Your healthcare provider may adjust your or your child's dose as needed, until the desired effect is achieved.

    If you have kidney impairment, your healthcare provider may adjust your dose appropriately.

  • How should I take this medication?

    Take Invega exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Invega without first talking to your healthcare provider.

    Take Invega with or without food.

    Swallow Invega tablets whole with liquids. Do not chew, divide, or crush the tablets.

    When you take Invega, you may see something in your stool that looks like a tablet. Do not be worried if you see this. It is the empty shell from the tablet after the medicine has been absorbed in your body.

  • What should I avoid while taking this medication?

    Do not drink alcohol while you are taking Invega.

    Do not drive, operate machinery, or engage in other dangerous activities until you know how Invega affects you.

    Do not get overheated or dehydrated while you are taking Invega. Drink plenty of water and do not over-exercise. Stay out of the sun, and do not wear too much or heavy clothing. In hot weather, stay in a cool place if possible.

  • What are the possible food and drug interactions associated with this medication?

    If Invega is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining Invega with the following: alcohol, carbamazepine, divalproex sodium, medications that slow down your brain function, or risperidone.

  • May I receive this medication if I am pregnant or breastfeeding?

    Invega may harm your newborn baby if you take it during the last few months of your pregnancy. Invega can be found in your breast milk if you take it while breastfeeding. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of this medication?

    If you miss a dose of Invega, skip the one you missed and return to your regular dosing schedule.

  • How should I store this medication?

    Store at room temperature. Protect from moisture.

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