Isosorbide Dinitrate

Generic Name: Isosorbide

  • What is this medication and its most common uses?

    Isosorbide dinitrate is a medicine used to prevent chest pain associated with coronary artery disease (narrowing of the small blood vessels that supply blood and oxygen to the heart).

  • What should I know when beginning and continuing on this medication?

    How does this medication work?

    Isosorbide dinitrate works by relaxing the blood vessels in your muscles, including your heart.

    What are the beneficial effects of this medication and when should I begin to have results?

    What: Isosorbide dinitrate has been shown to reduce chest pain associated with exercise.

    When: Isosorbide dinitrate may start working within 1 hour of taking a dose.

    How do I know it is working?

    You may feel an improvement in your chest pain after you start taking isosorbide dinitrate. This is a good indicator that the medicine is working. Your healthcare provider may ask you questions to assess how well your symptoms are controlled.

  • What are the possible side effects of this medication?

    The following is not a full list of side effects. Side effects cannot be anticipated. If any develop or change in intensity, tell your healthcare provider as soon as possible. Only your healthcare provider can determine if it is safe for you to continue taking this medication.

    More common side effects may include: headache.

    Less common side effects may include:

    Isosorbide dinitrate may cause lightheadedness, slow heart rate, or increased chest pain.

    Severe low blood pressure, especially if you also take a medicine called sildenafil.

  • Who should not take this medication?

    Do not take isosorbide dinitrate if you are allergic to it or any of its ingredients.

  • What should I tell my healthcare provider before I take the first dose of this medication?

    Tell your healthcare provider about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with isosorbide dinitrate. Also, talk to your healthcare provider about your complete medical history, especially if you have low blood pressure or heart problems (such as heart failure or a recent heart attack).

  • What is the usual dosage?

    The information below is based on the dosage guidelines your healthcare provider uses. Depending on your condition and medical history, your healthcare provider may prescribe a different regimen. Do not change the dosage or stop taking your medication without your healthcare provider's approval.

    Adults: The usual starting dose is 5 to 20 milligrams two or three times a day. Your healthcare provider may increase your dose as needed, until the desired effect is achieved.

    If you are elderly, your healthcare provider may adjust your dose appropriately.

  • How should I take this medication?

    Take isosorbide dinitrate exactly as prescribed by your healthcare provider.

    Your daily dosing schedule should include a 14-hour period without the medicine. Your healthcare provider will give you appropriate instructions.

  • What should I avoid while taking this medication?

    Do not change your dose or stop taking isosorbide dinitrate without first talking to your healthcare provider.

  • What are the possible food and drug interactions associated with this medication?

    If isosorbide dinitrate is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your healthcare provider before combining isosorbide dinitrate with alcohol.

  • May I receive this medication if I am pregnant or breastfeeding?

    The effects of isosorbide dinitrate during pregnancy and breastfeeding are unknown. Tell your healthcare provider immediately if you are pregnant, plan to become pregnant, or are breastfeeding.

  • What should I do if I miss a dose of this medication?

    If you miss a dose of isosorbide dinitrate, take it as soon as you remember. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

  • How should I store this medication?

    Store at room temperature. Protect from light.