What is Jakafi?Jakafi is a medicine used to treat people with certain types of myelofibrosis, including primary myelofibrosis, post-polycythemia vera myelofibrosis, and post-essential thrombocythemia myelofibrosis.
What is the most important information I should know about Jakafi?Jakafi can cause low platelet (type of blood cells that form clots to help stop bleeding) counts, low red blood cell counts, or low white blood cell counts. Your doctor will monitor your blood to check your blood cell counts before you start Jakafi and regularly during your treatment. Tell your doctor immediately if you develop unusual bleeding, bruising, fatigue, shortness of breath, or fever.
You may be at risk for developing a serious infection while you are taking Jakafi. Tell your doctor if you have chills, aches, fever, nausea, vomiting, weakness, or painful skin rash or blisters.
Who should not take Jakafi?Do not take Jakafi if you are allergic to it or any of its ingredients.
What should I tell my doctor before I take the first dose of Jakafi?Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Jakafi. Also, talk to your doctor about your complete medical history, especially if you have an infection, have or have had liver or kidney problems, are on dialysis, are pregnant, plan to become pregnant, or are breastfeeding.
What is the usual dosage?The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.
Adults: Your doctor will prescribe the appropriate dose for you based on your condition and platelet counts.
If you have kidney or liver impairment, your doctor will adjust your dose appropriately.
How should I take Jakafi?Take Jakafi exactly as prescribed by your doctor. You can take Jakafi with or without food. Do not stop taking Jakafi or change your dose without first consulting your doctor. Signs and symptoms of myelofibrosis are expected to return after stopping the treatment.
What should I avoid while taking Jakafi?Do not drink grapefruit juice while you are taking Jakafi. Grapefruit juice can affect the amount of medicine in your blood.
What are possible food and drug interactions associated with Jakafi?If Jakafi is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Jakafi with the following: boceprevir, clarithromycin, conivaptan, erythromycin, grapefruit juice, indinavir, itraconazole, ketoconazole, lopinavir/ritonavir, mibefradil, nefazodone, nelfinavir, posaconazole, rifampin, ritonavir, saquinavir, telaprevir, telithromycin, or voriconazole.
What are the possible side effects of Jakafi?Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.
Side effects include: body aches, bruising, chills, dizziness, fever, headache, nausea, painful skin rash or blisters, shortness of breath, tiredness, unusual bleeding, vomiting, weakness
Can I receive Jakafi if I am pregnant or breastfeeding?The effects of Jakafi during pregnancy and breastfeeding are unknown. Tell your doctor immediately if you are pregnant, plan to become pregnant, or are breastfeeding.
What should I do if I miss a dose of Jakafi?If you miss a dose of Jakafi, take your next dose at your regular time. Do not take two doses at once.
How should I store Jakafi?Store at room temperature.